Neuroprotective effects of Lepidium meyenii (Maca).
Pino-Figueroa A, Nguyen D, Maher TJ.
Department of Pharmaceutical Sciences, Massachusetts College of
Pharmacy and Health Sciences, Boston, Massachusetts 02115, USA.
The neuroprotective activity of the plant Lepidium meyenii (Maca) was
studied in two experimental models: in vitro and in vivo. Crayfish
neurons were pretreated with vehicle or the pentane extract from Maca,
subjected to H(2)O(2), and their viability determined microscopically
and chemically. A significant concentration-neuroprotective effect
relationship was demonstrated. The pentane extract was then
administered intravenously to rats prior to and following middle
cerebral artery occlusion. While infarct volumes were decreased for
the lower dose, higher doses increased infarct volumes compared to
controls. These results suggest a potential application of Maca as a
[PubMed - indexed for MEDLINE]