Name: Cor Kwant
About Me: Teacher, creator and webmaster of The Ginkgo Pages, a non-commercial awarded homepage about all aspects of the Ginkgo biloba tree, translated into German, French, Spanish and Dutch.
Su blog es: The Ginkgo Pages Forum - Blog
Incluye un interesante post en el que detalla las marcas de ginkgo que pasaron los tests de Consumerlab.
Nootrópicos (smartdrugs, drogas inteligentes, potenciadores cognitivos) son sustancias artificiales (medicamentos como piracetam, hydergina, citicolina, fosfatidilserina, vinpocetina, etc.) o naturales (suplementos nutricionales, vitaminas, aminoácidos, hormonas, hierbas, etc. como vitaminas B, piroglutamato, Gingko Biloba, fenilalanina, DHEA, pregnenolona, etc.) que se utilizan para mejorar la capacidad cognitiva (memoria, atención, etc.) en personas con trastornos o normales.
miércoles, septiembre 27, 2006
Atlas del cerebro
"We have essentially mapped each individual gene in the mouse brain, about 21,000 genes in all, down to the cellular level," said Allan Jones, chief scientific officer at the Allen Institute for Brain Science.
www.brainatlas.org
www.brainatlas.org
lunes, septiembre 11, 2006
quinasa M zeta proteina que refuerza la memoria
Noticia interesante a pesar de los errores de ortografía.
"El trabajo se publicó el pasado 25 de agosto en Science y en él se describe la encima llamada quinasa M zeta. Esta proteína conserva la memoria a largo plazo a través un refuerzo persistente de las conexiones sinápticas entre las neuronas. Inhibiendo la enzima los científicos fueron capaces de borrar los recuerdos almacenados en un día o incluso en un mes. Esta función en el almacenamiento de la memoria es específica de esta proteína porque inhibiendo otras moléculas similares no se obtienen los mismos resultados."
novaciencia
"El trabajo se publicó el pasado 25 de agosto en Science y en él se describe la encima llamada quinasa M zeta. Esta proteína conserva la memoria a largo plazo a través un refuerzo persistente de las conexiones sinápticas entre las neuronas. Inhibiendo la enzima los científicos fueron capaces de borrar los recuerdos almacenados en un día o incluso en un mes. Esta función en el almacenamiento de la memoria es específica de esta proteína porque inhibiendo otras moléculas similares no se obtienen los mismos resultados."
novaciencia
martes, septiembre 05, 2006
Nutricion y salud mental
Un artículo sobresimplificador y remanido (además de peligrosamente antifármacos) pero del que se puede sacar alguna recomendación.
Four brain chemicals -- serotonin, catecholamine, GABA and endorphin -- are essential for proper mental health, each affecting a different area of the brain. Some of us, unfortunately, have a genetic predisposition to lack these chemicals. Additionally, the modern mainstream diet is deficient in the amino acids that our brains need to make these neurotransmitters. As a result of these factors, incidence of depression and anxiety has reached epidemic proportions.
Achieve optimum mental health by supplementing deficient brain chemicals instead of resorting to dangerous antidepressant drugs
Four brain chemicals -- serotonin, catecholamine, GABA and endorphin -- are essential for proper mental health, each affecting a different area of the brain. Some of us, unfortunately, have a genetic predisposition to lack these chemicals. Additionally, the modern mainstream diet is deficient in the amino acids that our brains need to make these neurotransmitters. As a result of these factors, incidence of depression and anxiety has reached epidemic proportions.
Achieve optimum mental health by supplementing deficient brain chemicals instead of resorting to dangerous antidepressant drugs
domingo, septiembre 03, 2006
Idebenona si o no?
Hay opiniones encontradas sobre la conveniencia de usar idebenona (un análogo sintético de la Coenzima Q10 cuya acción se da principalmente a nivel de las mitocondrias). Algunos la acusan de ser pro-oxidante (superóxido).
Idebenona sí o idebenona no?
Idebenona sí o idebenona no?
viernes, septiembre 01, 2006
l-carnitina o acetil-l-carnitina?
A pesar de que muchos afirman que la acetil l-carnitina (ALCAR) es superior a la l-carnitina (especialmente para las mitocondrias y el cerebro), este artículo explica cómo una se transforma en la otra. Habrá que tener en cuenta también a los que usan ALCAR como juvenon.com . La carnitina es mucho más barata que la ALCAR por lo que no estaría mal empezar por la primera.
2. What form is best?
Pharmacologically speaking, there is little difference between supplementing with L-carnitine and supplementing with ALCAR. This is because ALCAR is deacetylated during or immediately after intestinal cell uptake, and then a certain amount of free carnitine is later reacetylated (1, 2). Similarly, it has been shown that supplementation with both L-carnitine and ALCAR increase tissue levels of both substances, and that the intestine creates significant amounts of ALCAR from carnitine (2, 3).
7. How should carnitine be taken?
The typical dosage for carnitine is 1-4 g/day (65). A study on the pharmacokinetics of oral L-carnitine in human subjects found no differences in plasma carnitine after 2 g vs. 6 g, indicating that 2 g is already more than the saturable dose (66). The half-life of the 2 gram dose was 6.5 hours, and this would imply that the ideal dosing schedule would be 1-2 grams 2-3 times daily, although many studies indicate beneficial effects with only .5-1.5 grams daily.
1. Iossa S, Mollica MP, Lionetti L, Crescenzo R, Botta M, Barletta A, Liverini G. Acetyl-L-carnitine supplementation differently influences nutrient partitioning, serum leptin concentration and skeletal muscle mitochondrial respiration in young and old rats. J Nutr 2002 Apr;132(4):636-42
2. Gross CJ, Henderson LM, Savaiano DA. Uptake of L-carnitine, D-carnitine and acetyl-L-carnitine by isolated guinea-pig enterocytes. Biochim Biophys Acta 1986 May 29;886(3):425-33 [abstract]
3. Gudjonsson H, Li BU, Shug AL, Olsen WA. In vivo studies of intestinal carnitine absorption in rats. Gastroenterology 1985 Jun;88(6):1880-7
L-Carnitine Description By David Tolson
2. What form is best?
Pharmacologically speaking, there is little difference between supplementing with L-carnitine and supplementing with ALCAR. This is because ALCAR is deacetylated during or immediately after intestinal cell uptake, and then a certain amount of free carnitine is later reacetylated (1, 2). Similarly, it has been shown that supplementation with both L-carnitine and ALCAR increase tissue levels of both substances, and that the intestine creates significant amounts of ALCAR from carnitine (2, 3).
7. How should carnitine be taken?
The typical dosage for carnitine is 1-4 g/day (65). A study on the pharmacokinetics of oral L-carnitine in human subjects found no differences in plasma carnitine after 2 g vs. 6 g, indicating that 2 g is already more than the saturable dose (66). The half-life of the 2 gram dose was 6.5 hours, and this would imply that the ideal dosing schedule would be 1-2 grams 2-3 times daily, although many studies indicate beneficial effects with only .5-1.5 grams daily.
1. Iossa S, Mollica MP, Lionetti L, Crescenzo R, Botta M, Barletta A, Liverini G. Acetyl-L-carnitine supplementation differently influences nutrient partitioning, serum leptin concentration and skeletal muscle mitochondrial respiration in young and old rats. J Nutr 2002 Apr;132(4):636-42
2. Gross CJ, Henderson LM, Savaiano DA. Uptake of L-carnitine, D-carnitine and acetyl-L-carnitine by isolated guinea-pig enterocytes. Biochim Biophys Acta 1986 May 29;886(3):425-33 [abstract]
3. Gudjonsson H, Li BU, Shug AL, Olsen WA. In vivo studies of intestinal carnitine absorption in rats. Gastroenterology 1985 Jun;88(6):1880-7
L-Carnitine Description By David Tolson
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