Aquí hay un buen artículo en Inglés:
http://examine.com/supplements/Ginkgo+biloba/
Han usado ginkgo biloba?
Nootrópicos (smartdrugs, drogas inteligentes, potenciadores cognitivos) son sustancias artificiales (medicamentos como piracetam, hydergina, citicolina, fosfatidilserina, vinpocetina, etc.) o naturales (suplementos nutricionales, vitaminas, aminoácidos, hormonas, hierbas, etc. como vitaminas B, piroglutamato, Gingko Biloba, fenilalanina, DHEA, pregnenolona, etc.) que se utilizan para mejorar la capacidad cognitiva (memoria, atención, etc.) en personas con trastornos o normales.
martes, septiembre 30, 2014
El ginkgo biloba
Aquí hay un buen artículo en Inglés:
http://examine.com/supplements/Ginkgo+biloba/
Han usado ginkgo biloba?
jueves, julio 17, 2014
Joe Rogan entrevista a la Dra Rhonda Patrick
miércoles, junio 11, 2014
¿Dónde comprar metilfolato en Argentina?
Me interesa conseguir metil folato (metiltetrahidrofolato, L-Methylfolate), la forma activa del ácido fólico.
¿Alguien sabe si se vende en farmacias o se puede comprar online en Argentina?Dra. Rhonda Patrick con Tim Ferriss sobre suplementos, nutrición, genes
The Tim Ferriss Show, Episode 12: Dr. Rhonda Patrick on Life Extension, Performance, and Much More
http://fourhourworkweek.com/2014/06/10/the-tim-ferriss-show-rhonda-patrick-life-extension/
Una buena entrevista a la Dra. Rhonda Patrick que trabaja con Bruce Ames, tratando temas de nutrientes, suplementos, salud, etc.
Les recomiendo seguirla:
http://www.foundmyfitness.com
http://www.twitter.com/founmyfitness
Tim Ferriss habla sobre nootrópicos y drogas inteligentes
Podcast #127 Tim Ferriss on Smart Drugs, Performance, and Biohacking http://www.bulletproofexec.com/127-tim-ferriss-on-smart-drugs-performance-and-biohacking-podcast/
jueves, marzo 06, 2014
50 mg de tiamina mejoran el humor y el tiempo de reacción
"Vitamin B1 – chemists call it
thiamine [structural formula on the
right] – is a mental pep pill. The
British psychologist reached this
conclusion in the 1990s. Benton got
female students to take 50 mg
vitamin B1 daily for two months and
discovered that his subjects' mood
improved and that their reactions
became quicker."
http://www.ergo-log.com/50-mg-vitamin-b1-supplement-improves-mood-speeds-up-reactions.html
thiamine [structural formula on the
right] – is a mental pep pill. The
British psychologist reached this
conclusion in the 1990s. Benton got
female students to take 50 mg
vitamin B1 daily for two months and
discovered that his subjects' mood
improved and that their reactions
became quicker."
http://www.ergo-log.com/50-mg-vitamin-b1-supplement-improves-mood-speeds-up-reactions.html
domingo, febrero 23, 2014
Twitter del blog: twitter.com/nootropicos
Hola, he creado una cuenta en Twitter para que vaya publicando las nuevas entradas en este blog. Es otra forma de mantenerse al tanto de las novedades. Para comunicación personal prefiero el blog o la lista en Yahoo. No sé si es muy buena práctica en twitter, pero creo que es útil. Iremos viendo.
Twitter de Nootrópicos: @nootropicos
twitter.com/nootropicos
martes, febrero 11, 2014
Día de protesta contra el espionaje de los gobiernos en internet
http://alt1040.com/2014/01/protesta-contra-espionaje-masivo
En inglés:
https://www.eff.org/nsa-spying
lunes, febrero 10, 2014
Entrevista con Dan Hurley sobre inteligencia
Buena entrevista en inglés para leer. La práctica, el ejercicio, n-back, el café y la nicotina parecen funcionar. Pero habla muchas cosas sobre inteligencia.
Ácido valproico y neuroplasticidad
That's the subject of an investigation by Takao Hensch, a professor of molecular and cellular biology at Harvard, who is studying a drug that may make it dramatically easier for grown-ups to absorb new skills and information — almost as if they were seven years old or younger.
http://theweek.com/article/index/254721/this-pill-could-give-your-brain-the-learning-powers-of-a-7-year-old
The key ingredient here is valproic acid. Normally, it's used to treat neurological disorders like seizures and epilepsy, and various other mood disorders. But Hensch claims it may help restore plasticity in the adult brain.
In a new experiment, Hensch used valproic acid to bestow the gift of perfect pitch to a group of adult males between the ages of 18 to 27.http://theweek.com/article/index/254721/this-pill-could-give-your-brain-the-learning-powers-of-a-7-year-old
viernes, diciembre 27, 2013
¿Dónde comprar teanina en Argentina?
Me interesaría probar el aminoácido l-teanina presente en el té verde en forma de cápsulas por sus supuestas propiedades para la calma y concentración y porque parece combina bien con la cafeína, pero no encuentro un vendedor en Argentina. He visto la página de Biovea pero dice que el envio se hace desde USA así que no me convence por posibles problemas con el correo o aduana.
Si alguien ha comprado teanina en Argentina por favor deje un comentario.
Gracias.
Si alguien ha comprado teanina en Argentina por favor deje un comentario.
Gracias.
viernes, noviembre 29, 2013
Comentaré sobre CILTEP
Estoy pensando hacer una entrada sobre la potenciación de la memoria a largo plazo con un suplemento a base de forskolina y extracto de alcachofa, conocido como CILTEP. Este producto desarrollado por Abelard Lindsay se ha hecho muy popular. Lamentablemente los componentes no son fáciles de conseguir en Argentina.
¿Alguien ha probado CILTEP?
miércoles, agosto 28, 2013
Tomando piracetam
Estoy tomando nuevamente piracetam. Hacía años que no lo probaba. Creo que me siento con más energía, pero como siempre pueden haber otras causas, así que dejo esta breve nota para actualizar luego.
¿Han probado piracetam? ¿Qué resultados tuvieron?
viernes, julio 12, 2013
Efectos cognitivos y emocionales del modafinilo y su modulación neuroquímica del cerebro
Se pueden bajar varios artículos sobre el efecto del modafinilo (en Argentina: FORCILIN,INTENSIT, NOPRAL 200,VIGICER) de http://www.sciencedirect.com/science/journal/00283908/64
La imagen es de: Linda Scorielsa, Peter B. Jonesa, Barbara J. Sahakian. Modafinil effects on cognition and emotion in schizophrenia and its neurochemical modulation in the brain. Neuropharmacology Volume 64, January 2013, Pages 168–184.
Sube muchos neurotransmisores menos GABA:
INCREASED
Dopamine Noradrenaline Glutamate Serotonin Histamine Orexin
DECREASED
GABA
Nota: el modafinilo es un estimulante del sistema nervioso central no anfetamínico que debe ser prescripto por un médico.
sábado, junio 22, 2013
smartdrugsmarts.com
Hay un sitio interesante en inglés http://smartdrugsmarts.com/ donde se pueden leer notas y escuchar podcasts (entrevistas en formato audio)
http://smartdrugsmarts.com/category/podcast-episode/
Sección sobre nootrópicos en reddit
Para el que sepà inglés, en el conocido sitio Reddit hay una sección sobre nootrópicos:
http://www.reddit.com/r/Nootropics/
Incluso hay un canal de chat IRC: IRC Chat: #reddit-nootropics on Freenode
Se puede usar el chat desde el navegador desde esta página:
http://webchat.freenode.net/?channels=reddit-nootropics
Hay que ingresar un nickname (apodo), las palabras del captcha y presionar Connect
domingo, diciembre 23, 2012
Pausas de 10 minutos para mejorar la memoria
En este interesante blog
http://www.rinconpsicologia.com/2012/12/quieres-mejorar-la-memoria-
realiza.html
leo:
En este estudio realizado en la Universidad de Edimburgo se apreció
que, cuando las personas hacían una pequeña pausa después de una
tarea de aprendizaje (como aprender una cadena de números), podían
recordarlos mejor, en comparación con quienes no tuvieron la
posibilidad de tomar un descanso que consolidara el aprendizaje.
Para verificar si esta teoría se podía aplicar realmente al recuerdo
de las historias, los investigadores fueron más allá de las cadenas
de números y le pidieron a los participantes que leyesen una historia.
Siete días después, debían narrar todos los detalles que recordasen.
El punto clave fue que algunos leyeron la historia
ininterrumpidamente y otros tomaron pausas de 10 minutos.
Una vez más, aquellos que habían leído la historia haciendo pausas,
mostraban un recuerdo mejor. Lo más sorprendente de todo es que este
recuerdo se podía equiparar con la cantidad de detalles que brindaban
las personas que habían leído la historia de un tirón, tan solo 15 o
30 minutos después.
http://www.rinconpsicologia.com/2012/12/quieres-mejorar-la-memoria-
realiza.html
leo:
En este estudio realizado en la Universidad de Edimburgo se apreció
que, cuando las personas hacían una pequeña pausa después de una
tarea de aprendizaje (como aprender una cadena de números), podían
recordarlos mejor, en comparación con quienes no tuvieron la
posibilidad de tomar un descanso que consolidara el aprendizaje.
Para verificar si esta teoría se podía aplicar realmente al recuerdo
de las historias, los investigadores fueron más allá de las cadenas
de números y le pidieron a los participantes que leyesen una historia.
Siete días después, debían narrar todos los detalles que recordasen.
El punto clave fue que algunos leyeron la historia
ininterrumpidamente y otros tomaron pausas de 10 minutos.
Una vez más, aquellos que habían leído la historia haciendo pausas,
mostraban un recuerdo mejor. Lo más sorprendente de todo es que este
recuerdo se podía equiparar con la cantidad de detalles que brindaban
las personas que habían leído la historia de un tirón, tan solo 15 o
30 minutos después.
viernes, diciembre 14, 2012
Mantener niveles de glucosa para sostener la motivación
n the researchers' discussion of the results, they said, "At its core,
self-regulatory change involves overriding one response in order to
enable a different response. The stronger the initial response or
impulse, the more difficult the self-control task will be—and, we
would assume, the greater amount of energy in the form of blood
glucose the system would have to expend in order to succeed."1 We
agree with the researchers that glucose is likely to provide only a
short-term help in counteracting the performance impairment resulting
from prior effortful self-control because there will be counteracting
metabolic factors (such as the need to release insulin in order to be
able to use the glucose for energy) that prevent maintaining a high
level of energy from a given amount of glucose for very long. It
would be like trying to maintain the energy increasing effects of
caffeine by drinking a cup of coffee again and again. That doesn't
work for very long because the factors that provide the lift from
caffeine, such as the release of noradrenaline, are depleted after a
while.
***In fact, you can extend the energy enhancing effect of caffeine by
taking nutrients the brain can use to make more noradrenaline, such
as the amino acids phenylalanine or tyrosine. In the case of glucose,
we would expect that taking nutrients along with glucose that improve
insulin sensitivity, such as chocolate, black tea, or cinnamon, might
extend the length of time you could extract energy from a given
amount of glucose.***
http://www.life-enhancement.com/magazine/article/2777-filling-your-
brains-fuel-tank-with-more-willpower
self-regulatory change involves overriding one response in order to
enable a different response. The stronger the initial response or
impulse, the more difficult the self-control task will be—and, we
would assume, the greater amount of energy in the form of blood
glucose the system would have to expend in order to succeed."1 We
agree with the researchers that glucose is likely to provide only a
short-term help in counteracting the performance impairment resulting
from prior effortful self-control because there will be counteracting
metabolic factors (such as the need to release insulin in order to be
able to use the glucose for energy) that prevent maintaining a high
level of energy from a given amount of glucose for very long. It
would be like trying to maintain the energy increasing effects of
caffeine by drinking a cup of coffee again and again. That doesn't
work for very long because the factors that provide the lift from
caffeine, such as the release of noradrenaline, are depleted after a
while.
***In fact, you can extend the energy enhancing effect of caffeine by
taking nutrients the brain can use to make more noradrenaline, such
as the amino acids phenylalanine or tyrosine. In the case of glucose,
we would expect that taking nutrients along with glucose that improve
insulin sensitivity, such as chocolate, black tea, or cinnamon, might
extend the length of time you could extract energy from a given
amount of glucose.***
http://www.life-enhancement.com/magazine/article/2777-filling-your-
brains-fuel-tank-with-more-willpower
viernes, octubre 05, 2012
Estudian cómo el té verde mejora la memoria
"We ran tests on two groups of mice, one which had imbibed EGCG and a
control group," said Bai. "First the mice were trained for three days
to find a visible platform in their maze. Then they were trained for
seven days to find a hidden platform."
The team found that the EGCG treated mice required less time to find
the hidden platform. Overall the results revealed that EGCG enhances
learning and memory by improving object recognition and spatial memory.
"We have shown that the organic chemical EGCG acts directly to
increase the production of neural progenitor cells, both in glass
tests and in mice," concluded Bai. "This helps us to understand the
potential for EGCG, and green tea which contains it, to help combat
degenerative diseases and memory loss."
http://wisciblog.com/2012/09/05/brainy-beverage-study-reveals-how-
green-tea-boosts-brain-cell-production-to-aid-memory/
control group," said Bai. "First the mice were trained for three days
to find a visible platform in their maze. Then they were trained for
seven days to find a hidden platform."
The team found that the EGCG treated mice required less time to find
the hidden platform. Overall the results revealed that EGCG enhances
learning and memory by improving object recognition and spatial memory.
"We have shown that the organic chemical EGCG acts directly to
increase the production of neural progenitor cells, both in glass
tests and in mice," concluded Bai. "This helps us to understand the
potential for EGCG, and green tea which contains it, to help combat
degenerative diseases and memory loss."
http://wisciblog.com/2012/09/05/brainy-beverage-study-reveals-how-
green-tea-boosts-brain-cell-production-to-aid-memory/
martes, agosto 07, 2012
La importancia de dormir
Dormir poco afecta la claridad de pensamiento aunque creamos que podemos adaptarnos.
La evaluación subjetiva falla, lo cual no es novedad y deberíamos tener en cuenta también cuando evaluamos tratamientos y suplementos.
http://www.bakadesuyo.com/how-little-sleep-can-you-get-away-with
La evaluación subjetiva falla, lo cual no es novedad y deberíamos tener en cuenta también cuando evaluamos tratamientos y suplementos.
http://www.bakadesuyo.com/how-little-sleep-can-you-get-away-with
La importancia de dormir
Dormir poco afecta la claridad de pensamiento aunque creamos que podemos adaptarnos.
La evaluación subjetiva falla, li cual no es novedad y deberíamos tener en cuenta también cuando vayamos tratamientos y suplementos.
http://www.bakadesuyo.com/how-little-sleep-can-you-get-away-with
La evaluación subjetiva falla, li cual no es novedad y deberíamos tener en cuenta también cuando vayamos tratamientos y suplementos.
http://www.bakadesuyo.com/how-little-sleep-can-you-get-away-with
martes, julio 17, 2012
Ginseng para problemas de atención?
J Diet Suppl. 2009;6(1):22-7.
Panax ginseng May Improve Some Symptoms of Attention-Deficit
Hyperactivity Disorder.
Niederhofer H.
Source
Child and Adolescent Psychiatry, Regional Hospital Bozen, Bolzano,
Italy.
Abstract
Objective. In this open trial, Panax ginseng, a serotonin and
norepinephrine reuptake inhibitor, actually used as an antidepressant,
has been investigated for its efficacy in the treatment of attention-
deficit hyperactivity disorder (ADHD) patients. Method. Three 14-17-
year-old male psychiatric outpatients, diagnosed with ADHD
disattention type have been rated at baseline and while taking Panax
ginseng to determine its efficacy as a treatment for ADHD.
Improvement was determined using comparisons of Conners' parent
ratings. Results. Patients' mean scores improved for Conners'
hyperactivity, inattention, and immaturity factors. Conclusions.
Although the sample size is very small and generalization is very
difficult, this observation indicates that Panax ginseng may be a
slightly effective treatment for ADHD.
PMID:
22435351
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22435351
Panax ginseng May Improve Some Symptoms of Attention-Deficit
Hyperactivity Disorder.
Niederhofer H.
Source
Child and Adolescent Psychiatry, Regional Hospital Bozen, Bolzano,
Italy.
Abstract
Objective. In this open trial, Panax ginseng, a serotonin and
norepinephrine reuptake inhibitor, actually used as an antidepressant,
has been investigated for its efficacy in the treatment of attention-
deficit hyperactivity disorder (ADHD) patients. Method. Three 14-17-
year-old male psychiatric outpatients, diagnosed with ADHD
disattention type have been rated at baseline and while taking Panax
ginseng to determine its efficacy as a treatment for ADHD.
Improvement was determined using comparisons of Conners' parent
ratings. Results. Patients' mean scores improved for Conners'
hyperactivity, inattention, and immaturity factors. Conclusions.
Although the sample size is very small and generalization is very
difficult, this observation indicates that Panax ginseng may be a
slightly effective treatment for ADHD.
PMID:
22435351
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22435351
martes, abril 24, 2012
Aumentar la inteligencia jugando dual n back
http://www.nytimes.com/2012/04/22/magazine/can-you-make-yourself-
smarter.html
smarter.html
Una nota sobre la inteligencia y la posibilidad discutida de
incrementarla con recursos como el juego dual n back.
El juego se consigue gratis incluso para celulares.
domingo, marzo 11, 2012
La repetición espaciada mejora la retención en el estudio
La repetición espaciada parece funcionar para estudiar:
Spacing out learning over time leads to drastically improved retention.
Via Annie Murphy Paul at Time:
In more than two dozen studies published over the past five years, he
has demonstrated that spaced repetition works, increasing knowledge
retention by up to 50 percent. And Kerfoot's method is easily adapted
by anyone who needs to learn and remember, not just those pursuing MDs.
And there's an easy way to implement this technique:
How can you learn like one of Kerfoot's Harvard Medical School
residents? Most email programs allow you to schedule the sending of
messages, making it easy to create a spaced-repetition course for
yourself. Divide up what you need to know—the text of a speech, the
material on an exam—into smaller units, no more than a few sentences
long. Then put the information into emails scheduled to be sent to
yourself at weekly intervals. To achieve the greatest memory-
strengthening effect, mix up old and new material, and put the
information in the form of a question to which you'll have to recall
the answer. You'll find that your email is making you smarter—no all-
nighters necessary.
http://www.bakadesuyo.com/what-can-you-learn-about-learning-from-harvar
miércoles, febrero 29, 2012
Suscripciones al grupo de discusión en Yahoo!
Hola, si tienen algún problema con la suscripción al grupo de discusión en Yahoo!
http://ar.groups.yahoo.com/group/nootropicos/
dejen un comentario aquí en el blog.
Para evitar el spam el grupo está configurado para requerir aprobación de cada nueva suscripción. A veces tardo en ver las notificaciones, pero los comentarios en el blog los veo más rápido.
Saludos.
http://ar.groups.yahoo.com/group/nootropicos/
dejen un comentario aquí en el blog.
Para evitar el spam el grupo está configurado para requerir aprobación de cada nueva suscripción. A veces tardo en ver las notificaciones, pero los comentarios en el blog los veo más rápido.
Saludos.
viernes, enero 13, 2012
Cómo incrementar la habilidad para estudiar
Consejos para mejorar la habilidad para estudiar basados en estudios
científicos:
científicos:
http://www.bakadesuyo.com/what-are-science-based-tips-for-increasing-yo
jueves, diciembre 15, 2011
La maca, otro caso en el que más no es mejor
Ann N Y Acad Sci. 2010 Jun;1199:77-85.
Neuroprotective effects of Lepidium meyenii (Maca).
Pino-Figueroa A, Nguyen D, Maher TJ.
Source
Neuroprotective effects of Lepidium meyenii (Maca).
Pino-Figueroa A, Nguyen D, Maher TJ.
Source
Department of Pharmaceutical Sciences, Massachusetts College of
Pharmacy and Health Sciences, Boston, Massachusetts 02115, USA.
alejandro.pino@my.mcphs.edu
Abstract
The neuroprotective activity of the plant Lepidium meyenii (Maca) was
studied in two experimental models: in vitro and in vivo. Crayfish
neurons were pretreated with vehicle or the pentane extract from Maca,
subjected to H(2)O(2), and their viability determined microscopically
and chemically. A significant concentration-neuroprotective effect
relationship was demonstrated. The pentane extract was then
administered intravenously to rats prior to and following middle
cerebral artery occlusion. While infarct volumes were decreased for
the lower dose, higher doses increased infarct volumes compared to
controls. These results suggest a potential application of Maca as a
neuroprotectant.
PMID:
20633111
[PubMed - indexed for MEDLINE]
sábado, diciembre 10, 2011
Dos estudios sobre el guaraná
Dos interesantes estudios (texto completo) sobre el guaraná el el
sitio de una babiba energizante isaraelí http://www.drinkwakeup.com/
sitio de una babiba energizante isaraelí http://www.drinkwakeup.com/
Guarana
A clinical study conducted by the British Psychopharmacology Board
published in 2007 in the Journal of Psychopharmacology examined the
range of effects of a standard Guarana extract of varying dosages (37.
5 mg, 75 mg, 150 mg, 300 mg). Results proved that the lowest dosages
achieved the best results, although in all dosages there was an
improvement in the secondary memory, alertness and mood.
http://www.drinkwakeup.com/contentManagment/uploadedFiles/fileGallery/
guarana.pdf
Lo cual muestra que más no siemrpe es mejor.
Guarana Versus Coffee
A comparative research between Guarana, Coffee and Yerba Mate studied
the effectiveness towards improved alertness during the noontime. The
results of this study have shown that Guarana is more effective than
coffee and Yerba Mate in improving alertness
viernes, diciembre 09, 2011
Encuentran una molécula en cuya ausencia la memoria de los mamíferos se multiplica
Un equipo de científicos del Baylor College of Medicine (BCM) de
Houston (Texas) parece haber encontrado una molécula en cuya ausencia
la memoria de los mamíferos se multiplica.
Houston (Texas) parece haber encontrado una molécula en cuya ausencia
la memoria de los mamíferos se multiplica.
La molécula en cuestión es la PKR, estudiada durante años por su
labor como protectora de los mamíferos contra infecciones virales.
Pero el equipo liderado por el doctor Mauro Costa-Matiolli, profesor
de neurociencia en BCM, observó que la actividad de esta molécula
aparecía modificada cuando un paciente presentaba algún tipo de
desorden cognitivo, por lo que comenzaron a estudiar su función en el
cerebro.
http://www.abc.es/20111208/ciencia/abci-memoria-201112081932.html
lunes, octubre 17, 2011
¿Azul de metileno como nootrópico?
Sí, el azul de metileno es el líquido azul que comunmente se usa para
tratar las peceras.
tratar las peceras.
Cito de
http://www.cuantaciencia.com/ciencia/azul-metileno-alzheimer
"Como bien dijera Pasteur, la fortuna juega a favor de una mente
preparada y Wischik se dedicó a leer lo que otros científicos sabían
sobre este tipo de tinciones. Se enteró de que el azul de metileno se
podía utilizar para luchar contra las infecciones urinarias y de que
algunos psiquiatras lo emplean para tratar a los maníaco depresivos.
Aunque le llevo su tiempo, diez años después fue capaz de demostrar
que el azul de metileno evita la agregación de proteínas causante del
Alzheimer. Administrado a 321 enfermos de Alzheimer, vieron que se
retrasaba el deterioro de sus funciones cognitivas.
Inspirada por el éxito de sus investigaciones, en el 2.002 se muda a
Singapur y funda TauRx. Así, Rember es el primer tratamiento diseñado
contra la formación de placas en el cerebro de los enfermos de
Alzheimer."
Entrevista al Dr Ames:
Super Human Radio Show # 529 - BEST OF - 100 Yr Old Dye Reverses
Brain Aging And May Cure Alzheimer's Disease
de Super Human Radio
# 529 - BEST OF - 100 Yr Old Dye Reverses Brain Aging And May Cure
Alzheimer's Disease :: Guest: Dr. Bruce Ames :: Just a little over
100 years ago the first synthetic dye used in the lab was formulated -
Methylene Blue. Research has shown that this compound may possess far
greater benefits than highlighting a specimen. ::
http://www.podcastdirectory.com/podshows/8248518 (audio)
Potential Alzheimer's, Parkinson's Cure Found In Century-old Drug
A paper on the methylene blue study, conducted by Hani Atamna, PhD,
and Dr. Atamna's research, funded by the Bruce and Giovanna Ames .
http://www.sciencedaily.com/releases/2008/08/080818101335.htm
Escribir como técnica para superar la ansiedad ante los exámenes
Reproduzco una nota del interesante blog Rincón de la Psicología.
Todos nosotros, alguna que otra vez nos hemos enfrentado a la
ansiedad ante los exámenes, ya sean las pruebas escolásticas, el
examen de conducción o un test laboral. Esta ansiedad proviene en
gran parte del hecho de que nos sentimos valorados, sabemos que se
juzgará nuestro desempeño y deseamos obtener el mayor puntaje posible.
No obstante, hay personas que sienten tal ansiedad que esta les
impide lograr una buena calificación, aún cuando son capaces y
manejan todas las informaciones necesarias para pasar con éxito la
prueba.
Algunas personas, en aras de calmarse, recurren a los psicofármacos o
a la terapia floral. Otras más conocedoras de la psiquis humana se
someten a una sesión de relajación pero lo cierto es que existe una té
cnica aún más sencilla para vencer la ansiedad ante los exámenes:
escribir en un papel las sensaciones que estamos experimentando.
Un estudio recientemente publicado en la revista Science y
desarrollado en la Universidad de Chicago ha venido a demostrar
experimentalmente la eficacia de esta técnica.
Los investigadores sometieron a un grupo de estudiantes
universitarios a dos pruebas de tipo matemático. La primera se utilizó
como prueba control para determinar el desempeño de base y en el
segundo examen se le puntualizó que los resultados obtenidos se añadir
ían a sus notas de escuela.
Lo interesante fue que a la mitad de los estudiantes se les pidió que
escribieran sus miedos apenas diez minutos antes de aplicarle el test.
¿Cuál fue el resultado?
Los estudiantes que escribieron sus preocupaciones obtuvieron un
puntaje mejor en comparación con el primer test, específicamente, un 5%
mejor. Sin embargo, los estudiantes que simplemente se enfrentaron al
examen con el estrés añadido puntuaron peor, exactamente un 12%. Este
hecho no solo confirma que el miedo y la ansiedad disminuyen nuestro
desempeño sino que escribir sobre nuestros estados de ánimo nos
permite controlar nuestros miedos. ¿Por qué?
Una de las explicaciones posibles es que escribir sobre nuestros
estados de ánimo nos permite reflexionar sobre sus causas y asumir
cierta distancia de los mismos. De esta manera nos percatamos que
muchos de nuestros temores no tienen un verdadero sentido por lo que
somos capaces de vencerlos. Probablemente por esta razón, cuando aún
no existía la Psicología, ya las personas tenían la costumbre de
realizar diarios pues conocían el poder terapéutico del lápiz.
http://www.rinconpsicologia.com/2011/10/ansiedad-ante-los-examenes-
como.html
sábado, junio 11, 2011
Técnicas de estudio
La Wikipedia en Español tiene un artículo interesante sobre Técnicas
de estudio:
de estudio:
martes, abril 12, 2011
Suscribirse a los comentarios del blog
Estoy viendo que falta un link a la suscripción a los comentarios de
todo el blog.
todo el blog.
Pueden hacerlo a través de este:
http://nootropicos.blogspot.com/feeds/comments/full
Después veo si puedo actualizar la plantilla.
viernes, marzo 04, 2011
Agomelatina como nootropico?
The antidepressant agomelatine blocks the adverse effects of stress
on memory and enables spatial learning to rapidly increase neural
cell adhesion molecule (NCAM) expression in the hippocampus of rats
on memory and enables spatial learning to rapidly increase neural
cell adhesion molecule (NCAM) expression in the hippocampus of rats
by
Conboy L, Tanrikut C, Zoladz PR, Campbell AM,
Park CR, Gabriel C, Mocaer E, Sandi C, Diamond DM.
Laboratory of Behavioural Genetics,
Brain Mind Institute, EPFL,
Lausanne, Switzerland.
Int J Neuropsychopharmacol. 2008 Aug 18:1-13.
ABSTRACT
Agomelatine, a novel antidepressant with established clinical efficacy,
acts as a melatonin receptor agonist and 5-HT2C receptor antagonist.
As stress is a significant risk factor in the development of
depression, we sought to determine if chronic agomelatine treatment
would block the stress-induced impairment of memory in rats trained
in the radial-arm water maze (RAWM), a hippocampus-dependent spatial
memory task. Moreover, since neural cell adhesion molecule (NCAM) is
known to be critically involved in memory consolidation and synaptic
plasticity, we evaluated the effects of agomelatine on NCAM, and
polysialylated NCAM (PSA-NCAM) expression in rats given spatial
memory training with or without predator stress. Adult male rats were
pre-treated with agomelatine (10 mg/kg i.p., daily for 22 d),
followed by a single day of RAWM training and memory testing. Rats
were given 12 training trials and then they were placed either in
their home cages (no stress) or near a cat (predator stress). Thirty
minutes later the rats were given a memory test trial followed
immediately by brain extraction. We found that: (1) agomelatine
blocked the predator stress-induced impairment of spatial memory; (2)
agomelatine-treated stressed, as well as non-stressed, rats exhibited
a rapid training-induced increase in the expression of synaptic NCAM
in the ventral hippocampus; and (3) agomelatine treatment blocked the
water-maze training-induced decrease in PSA-NCAM levels in both
stressed and non-stressed animals.
This work provides novel observations which indicate that agomelatine
blocks the adverse effects of stress on hippocampus-dependent memory
and activates molecular mechanisms of memory storage in response to a
learning experience.
domingo, octubre 24, 2010
Técnicas de estudio que dan resultado según investigaciones
Este es un artículo en Inglés sobre nuevos estudios sobre técnicas de
estudio.
estudio.
Parece que lo que funciona es:
- alternar los contextos donde se estudia
- combinar contenidos
- espaciar las sesiones de estudio
- auto evaluaciones
viernes, octubre 22, 2010
Vitamina A y D en los suplementos
Interesante artículo sobre la vitamina A y la D
As far as I know, low doses of beta-carotene (1,000–2,000 IU per day)
will not do too much harm. The best way to get vitamin D substrate,
as far as I can tell, is to take at least 5,000 IU of vitamin D3 per
day in the winter and stop all vitamin D in the summer and sunbathe.
Alternatively, use a tanning bed when the sun is too low on the
horizon to sunbathe. Remember, when you are outside, if your shadow
is longer than you are, you are not making any vitamin D.
http://www.vitamindcouncil.org/newsletter/2008-december.shtml
La mayoría de los multivitamínicos traen vitamina A, en realidad casi
todos vienen sin las mejores fromas de las vitaminas y minerales.
viernes, octubre 01, 2010
Cambio de plantilla
Como la anterior plantilla daba problemas traté de actualizar a una nueva.
No logro que los links queden en una barra a la izqueirda en vez de abajo. Disculpen lo desprolijo.
Edit: ahora parece que anda, revisé los posts en formato html para ver errores o problemas y quité algún código que molestaba, no sabría bién cuál, pero puede ser tablas o span.
No logro que los links queden en una barra a la izqueirda en vez de abajo. Disculpen lo desprolijo.
Edit: ahora parece que anda, revisé los posts en formato html para ver errores o problemas y quité algún código que molestaba, no sabría bién cuál, pero puede ser tablas o span.
domingo, agosto 01, 2010
Dra Nancy C. Andreasen
Esta es la Dra de la que habla Dr Fidel en el video: Nancy C. Andreasen, autora de The Creating Brain: The Neuroscience of Genius
http://www.amazon.com/Creating-Brain-Neuroscience-Genius/dp/1932594078
http://en.wikipedia.org/wiki/Nancy_Coover_Andreasen
Me gustó esto de
http://www.pbs.org/kcet/closertotruth/ask/andreasen.html
What advice do you have for young people?
It's important to recognize that you're going to have a lot of failures, especially if you're a gifted person you're going to receive a lot of criticism and so you have to be willing to accept rejection over and over and pick yourself up and persist even if people doubt you or turn down your papers or whatever they happen to do, so persist and work hard. I guess another important thing is to find something that you really think is important that you care about passionately and pursue that.
http://www.amazon.com/Creating-Brain-Neuroscience-Genius/dp/1932594078
http://en.wikipedia.org/wiki/Nancy_Coover_Andreasen
Me gustó esto de
http://www.pbs.org/kcet/closertotruth/ask/andreasen.html
What advice do you have for young people?
It's important to recognize that you're going to have a lot of failures, especially if you're a gifted person you're going to receive a lot of criticism and so you have to be willing to accept rejection over and over and pick yourself up and persist even if people doubt you or turn down your papers or whatever they happen to do, so persist and work hard. I guess another important thing is to find something that you really think is important that you care about passionately and pursue that.
Cerebro creativo por Dr. Fidel
"Existen nuevos descubrimientos que demuestran que existen cerebros que más fácilmente pueden hacer adicciones. Esta investigación permitirá elaborar sistemas de prevención y tratamiento más efectivos…"
http://www.youtube.com/watch?v=f4RvvTKXoBY
pps y ppt
http://drfidel.com/index.php?option=com_content&view=category&id=7&Itemid=14&limitstart=10
http://www.youtube.com/watch?v=f4RvvTKXoBY
pps y ppt
http://drfidel.com/index.php?option=com_content&view=category&id=7&Itemid=14&limitstart=10
lunes, julio 19, 2010
La memoria en la creatividad
La importancia de la memoria de proceso:
"However, while intelligence and preparation may be necessary, they may not be enough to produce creativity. "Maybe it's working memory capacity that is the protective aspect," Carson says. "How many things can you hold in your mind and process and manipulate?" In a preliminary, unpublished study, she says, "The combination of low latent inhibition and high working memory also predicted creative achievement."
de:
The DaVinci Mode
Ideas Rain In
by Craig Lambert
http://harvardmagazine.com/2004/05/ideas-rain-in.html
"However, while intelligence and preparation may be necessary, they may not be enough to produce creativity. "Maybe it's working memory capacity that is the protective aspect," Carson says. "How many things can you hold in your mind and process and manipulate?" In a preliminary, unpublished study, she says, "The combination of low latent inhibition and high working memory also predicted creative achievement."
de:
The DaVinci Mode
Ideas Rain In
by Craig Lambert
http://harvardmagazine.com/2004/05/ideas-rain-in.html
Más sobre creatividad y rasgos psicológicos
Biological Basis For Creativity Linked To Mental Illness
http://www.sciencedaily.com/releases/2003/10/031001061055.htm
Low Latent Inhibition Plus High Intelligence Leads To High Creativity?
http://www.futurepundit.com/archives/001684.html
http://www.sciencedaily.com/
Low Latent Inhibition Plus High Intelligence Leads To High Creativity?
http://www.futurepundit.com/
Nutrición, creatividad y rasgos psicológicos
Este artículo se encontraba en creativesubstances.com/nutritio-and-creativity pero desapareció.
A fines de archivo y porque es interesante lo pongo aquí. Si alguien tiene el artículo con los links, me interesa tenerlo. Creo que el autor se llama Ryan.
Creative Substances
January 18, 2009
Nutrition and Creativity
Filed under: Uncategorized — @ 11:23 am
Can nutrition and supplements enhance creativity? This is a question
I have been exploring for several years now. I have discovered a
wealth of scientific information that supports and/or suggests a
potential influence, but I have had a harder time finding feedback
from people consciously using nutrition and supplementation to
increase creativity. And so I have created this website to combine
the latest scientific discoveries with my own experimentation.
First, what are the scientific underpinnings of creativity? Recent
research into creativity has identified two important traits common
to creative individuals: schizotypy and low latent inhibition.
Schizotypy, as the name implies, refers to a set of personality
traits related to schizophrenia. An important distinction here is
that it is possible to have schizotypal traits and not actually have
schizophrenia. In short, there are four general schizotypal traits:
unusual experiences, cognitive disorganization, introverted anhedonia,
and impulsive non-conformity. The first two are considered "positive"
schizotypal traits while the latter two are called "negative."
Daniel Nettle published a study in which he analyzed the schizotypal
tendencies of artists and mathematicians, and observed that
successful poets and artists score higher in the first two categories
than the average population. Introverted anhedonia, or the inability
to experience pleasure was negatively correlated with success in all
artistic domains. His study can be found here.
Cognitive disorganization is strongly related to the second major
recent discovery about creative individuals – low latent inhibition.
Latent inhibition (LI) refers to the ability to screen out irrelevant
stimuli from conscious awareness. Historically, low LI has been
associated with psychosis, since people with schizophrenia and
bipolar disorder usually display low latent inhibition on common
tests of attention. Shelley H. Carson headed a study of Harvard
undergraduates which added an interesting twist to the old assumption.
Her study found that high lifetime creative achievement is strongly
correlated with low latent inhibition and high IQ. The idea is that
low latent inhibition can predispose individuals to either psychosis
or exceptional creativity, depending on the moderating influence of
intelligence. Of course, low latent inhibition could predispose
someone to both creativity and psychosis, which may help explain the
longstanding link between genius and insanity. As the poet Dryden
wrote in 17th century England, "great wits are sure to madness near
allied, and thin partitions do their bounds divide."
So there appears to be a link between schizotypal tendencies, low
latent inhibition and creative achievement. Dr. Keith Simonton noted
another important trend among highly creative individuals: they tend
to produce a lot and the quality of their work remains fairly constant.
Beethoven's greatest works, for example, were all produced during his
most prolific periods when he also created a lot of now largely
ignored pieces. Over the course of his life, Beethoven's probability-
of-success remained constant. For the rest of us this means that the
more we produce the better our chances of creating our finest work,
even if we have to sift through a lot of dirt to reach the gold. Go
here for a great summary of Dr. Simonton's work.
Having discussed the major recent discoveries about creativity, let's
return to the original question: can nutrition enhance creativity?
We now have some specific goals in mind through which to analyze the
influence of nutrition and supplements. We are looking to lower
latent inhibition (subjectively comparable to a rush of ideas). We
are looking to increase productivity. Shared among these is the
influence of dopamine, particularly in the mesolimbic pathway of the
brain. Increasing dopamine is therefore one target of our
nutritional approach to enhancing creativity.
First, let's consider supplements that may enhance creativity. I
have limited my research for the most part to naturally occurring
substances that the reader can easily obtain. Of course, you could
just take 5 mg. of d-amphetamine, which has been repeatedly shown to
reduce latent inhibition. However, I would like to focus on more
sustainable ways of enhancing creativity. The most effective "natural
" supplements I have found are SAM-e and NADH. Both are naturally
occurring in the human body and indirectly influence dopamine levels.
I have also experimented with deprenyl (selegiline). Although not a
naturally occurring substance, deprenyl does influence dopamine
levels and has been used to increase lifespan in laboratory animals.
My own experiments with deprenyl have been less than stellar, so I
only mention it as a hypothetical creativity enhancer which hasn't
really worked for me personally. I have also used amino acids like l-
tyrosine and l-phenylalanine (both precursors of dopamine) but with
likewise inconsistent effects. As an interesting alternative I would
mention the combination of maca and horny goat weed (epimedium).
Although usually combined to make a well-studied herbal aphrodisiac,
I believe the hormonal effects of these two herbs can influence
creativity. Maybe they just make you so horny that your drive to
create intensifies as well — but if it works, it works.
Lest we dwell too much on the healthy creativity enhancers, let's not
forget the old standby alcohol. Can dozens of famously alcoholic
writers and poets be wrong? There has been some scientific research
into the role of alcohol in the creative process, with one Finnish
study suggesting that it can definitely be useful in the incubation
phase. Assuming that alcohol can play a productive role in creativity,
you might want to make red wine your alcohol of choice.
Secondly, let's consider dietary approaches. When we eat, what we eat,
and how much we eat all have an influence on mood and attention. So
why shouldn't diet also influence creativity? I once spent a period
of about six months attempting to replicate the Ancient Greek diet.
I ate lots of fish and barley. Why on earth would I do such a thing?
Well, the culture of ancient Athens in particular produced more
geniuses per capita than any other culture before or since. What
they actually ate may not have had anything to do with it, but I felt
it was a worthwhile experiment nonetheless. Most recently diets that
imitate hunter-gatherer diets have attracted a lot of attention.
These diets usually exclude grains and as a result are relatively low
on carbohydrates. In my own experiments I have found hunter-gatherer
or Paleolithic-type diets to have an energizing effect. When
sticking to them I never felt the need for a nap in the middle of the
day, and I regularly experienced intensely euphoric moments. What
about the more mundane substances we daily choose to ingest? Coffee,
cocoa, and green tea all have a place in creative work.
Thirdly, let's consider daily habits. What about the influence of
exercise, sleep, sex, and light exposure on creativity? Can we learn
anything from the daily habits of eminent creators?
I started this website in order to share my own experiences with
nutrition and creativity, and I'd like to invite others to post their
own experiences below and in the other pages of this site.
Home
6 Comments »
1.
[...] creativity? Levels of SAM-e appear to be elevated in
children and in euphoric and manic people. As I've mentioned before,
creative individuals display many similarities to schizophrenics and
manic depressives. Dopamine [...]
Pingback by SAM-e – Does it Boost Creativity? «
creativesubstances.com — January 21, 2009 @ 9:00 pm
2.
[...] does make me think almost immediately of low latent
inhibition. As I've mentioned before, low latent inhibition appears
to be a quality common to creative individuals. Because they do not
filter stimuli as [...]
Pingback by The Insomniac's Muse: Sleep, Sleeplessness, and
Creativity « Creative Substances — January 22, 2009 @ 11:03 pm
3.
[...] adenine dinucleotide) increases dopamine via the enzyme
tyrosine hydroxylase. The influence of dopamine has been linked to
creative thinking in countless studies, and I have found NADH
especially useful for late night creative [...]
Pingback by Six Natural Ways to Enhance Creativity « Creative
Substances — January 28, 2009 @ 7:21 pm
4.
[...] few studies which suggest that it may be able to enhance
dopamine neurotransmission in the brain. Dopamine has been linked to
creative drive and idea generation in many studies, and enhancing
dopamine appears to be a significant approach to boosting [...]
Pingback by Arachidonic Acid Increases Dopamine « Creative
Substances — February 10, 2009 @ 10:01 pm
5.
[...] than in larger doses. It tends to simultaneously relax
the body while disinhibiting the mind (and lowering latent inhibition).
A single drink is probably best, and possible a second if a snack is
involved to help slow down [...]
Pingback by How Does Alcohol Affect Creativity? « Creative
Substances — February 18, 2009 @ 7:05 pm
6.
[...] selection favoring creativity. That is, creative people
tend to attract more partners, and the same genes that confer
heightened creativity can also lead to affective diseases. One
highly publicized study found that professional artists [...]
Pingback by Sex and Creativity « Creative Substances — February
20, 2009 @ 4:45 pm
A fines de archivo y porque es interesante lo pongo aquí. Si alguien tiene el artículo con los links, me interesa tenerlo. Creo que el autor se llama Ryan.
Creative Substances
January 18, 2009
Nutrition and Creativity
Filed under: Uncategorized — @ 11:23 am
Can nutrition and supplements enhance creativity? This is a question
I have been exploring for several years now. I have discovered a
wealth of scientific information that supports and/or suggests a
potential influence, but I have had a harder time finding feedback
from people consciously using nutrition and supplementation to
increase creativity. And so I have created this website to combine
the latest scientific discoveries with my own experimentation.
First, what are the scientific underpinnings of creativity? Recent
research into creativity has identified two important traits common
to creative individuals: schizotypy and low latent inhibition.
Schizotypy, as the name implies, refers to a set of personality
traits related to schizophrenia. An important distinction here is
that it is possible to have schizotypal traits and not actually have
schizophrenia. In short, there are four general schizotypal traits:
unusual experiences, cognitive disorganization, introverted anhedonia,
and impulsive non-conformity. The first two are considered "positive"
schizotypal traits while the latter two are called "negative."
Daniel Nettle published a study in which he analyzed the schizotypal
tendencies of artists and mathematicians, and observed that
successful poets and artists score higher in the first two categories
than the average population. Introverted anhedonia, or the inability
to experience pleasure was negatively correlated with success in all
artistic domains. His study can be found here.
Cognitive disorganization is strongly related to the second major
recent discovery about creative individuals – low latent inhibition.
Latent inhibition (LI) refers to the ability to screen out irrelevant
stimuli from conscious awareness. Historically, low LI has been
associated with psychosis, since people with schizophrenia and
bipolar disorder usually display low latent inhibition on common
tests of attention. Shelley H. Carson headed a study of Harvard
undergraduates which added an interesting twist to the old assumption.
Her study found that high lifetime creative achievement is strongly
correlated with low latent inhibition and high IQ. The idea is that
low latent inhibition can predispose individuals to either psychosis
or exceptional creativity, depending on the moderating influence of
intelligence. Of course, low latent inhibition could predispose
someone to both creativity and psychosis, which may help explain the
longstanding link between genius and insanity. As the poet Dryden
wrote in 17th century England, "great wits are sure to madness near
allied, and thin partitions do their bounds divide."
So there appears to be a link between schizotypal tendencies, low
latent inhibition and creative achievement. Dr. Keith Simonton noted
another important trend among highly creative individuals: they tend
to produce a lot and the quality of their work remains fairly constant.
Beethoven's greatest works, for example, were all produced during his
most prolific periods when he also created a lot of now largely
ignored pieces. Over the course of his life, Beethoven's probability-
of-success remained constant. For the rest of us this means that the
more we produce the better our chances of creating our finest work,
even if we have to sift through a lot of dirt to reach the gold. Go
here for a great summary of Dr. Simonton's work.
Having discussed the major recent discoveries about creativity, let's
return to the original question: can nutrition enhance creativity?
We now have some specific goals in mind through which to analyze the
influence of nutrition and supplements. We are looking to lower
latent inhibition (subjectively comparable to a rush of ideas). We
are looking to increase productivity. Shared among these is the
influence of dopamine, particularly in the mesolimbic pathway of the
brain. Increasing dopamine is therefore one target of our
nutritional approach to enhancing creativity.
First, let's consider supplements that may enhance creativity. I
have limited my research for the most part to naturally occurring
substances that the reader can easily obtain. Of course, you could
just take 5 mg. of d-amphetamine, which has been repeatedly shown to
reduce latent inhibition. However, I would like to focus on more
sustainable ways of enhancing creativity. The most effective "natural
" supplements I have found are SAM-e and NADH. Both are naturally
occurring in the human body and indirectly influence dopamine levels.
I have also experimented with deprenyl (selegiline). Although not a
naturally occurring substance, deprenyl does influence dopamine
levels and has been used to increase lifespan in laboratory animals.
My own experiments with deprenyl have been less than stellar, so I
only mention it as a hypothetical creativity enhancer which hasn't
really worked for me personally. I have also used amino acids like l-
tyrosine and l-phenylalanine (both precursors of dopamine) but with
likewise inconsistent effects. As an interesting alternative I would
mention the combination of maca and horny goat weed (epimedium).
Although usually combined to make a well-studied herbal aphrodisiac,
I believe the hormonal effects of these two herbs can influence
creativity. Maybe they just make you so horny that your drive to
create intensifies as well — but if it works, it works.
Lest we dwell too much on the healthy creativity enhancers, let's not
forget the old standby alcohol. Can dozens of famously alcoholic
writers and poets be wrong? There has been some scientific research
into the role of alcohol in the creative process, with one Finnish
study suggesting that it can definitely be useful in the incubation
phase. Assuming that alcohol can play a productive role in creativity,
you might want to make red wine your alcohol of choice.
Secondly, let's consider dietary approaches. When we eat, what we eat,
and how much we eat all have an influence on mood and attention. So
why shouldn't diet also influence creativity? I once spent a period
of about six months attempting to replicate the Ancient Greek diet.
I ate lots of fish and barley. Why on earth would I do such a thing?
Well, the culture of ancient Athens in particular produced more
geniuses per capita than any other culture before or since. What
they actually ate may not have had anything to do with it, but I felt
it was a worthwhile experiment nonetheless. Most recently diets that
imitate hunter-gatherer diets have attracted a lot of attention.
These diets usually exclude grains and as a result are relatively low
on carbohydrates. In my own experiments I have found hunter-gatherer
or Paleolithic-type diets to have an energizing effect. When
sticking to them I never felt the need for a nap in the middle of the
day, and I regularly experienced intensely euphoric moments. What
about the more mundane substances we daily choose to ingest? Coffee,
cocoa, and green tea all have a place in creative work.
Thirdly, let's consider daily habits. What about the influence of
exercise, sleep, sex, and light exposure on creativity? Can we learn
anything from the daily habits of eminent creators?
I started this website in order to share my own experiences with
nutrition and creativity, and I'd like to invite others to post their
own experiences below and in the other pages of this site.
Home
6 Comments »
1.
[...] creativity? Levels of SAM-e appear to be elevated in
children and in euphoric and manic people. As I've mentioned before,
creative individuals display many similarities to schizophrenics and
manic depressives. Dopamine [...]
Pingback by SAM-e – Does it Boost Creativity? «
creativesubstances.com — January 21, 2009 @ 9:00 pm
2.
[...] does make me think almost immediately of low latent
inhibition. As I've mentioned before, low latent inhibition appears
to be a quality common to creative individuals. Because they do not
filter stimuli as [...]
Pingback by The Insomniac's Muse: Sleep, Sleeplessness, and
Creativity « Creative Substances — January 22, 2009 @ 11:03 pm
3.
[...] adenine dinucleotide) increases dopamine via the enzyme
tyrosine hydroxylase. The influence of dopamine has been linked to
creative thinking in countless studies, and I have found NADH
especially useful for late night creative [...]
Pingback by Six Natural Ways to Enhance Creativity « Creative
Substances — January 28, 2009 @ 7:21 pm
4.
[...] few studies which suggest that it may be able to enhance
dopamine neurotransmission in the brain. Dopamine has been linked to
creative drive and idea generation in many studies, and enhancing
dopamine appears to be a significant approach to boosting [...]
Pingback by Arachidonic Acid Increases Dopamine « Creative
Substances — February 10, 2009 @ 10:01 pm
5.
[...] than in larger doses. It tends to simultaneously relax
the body while disinhibiting the mind (and lowering latent inhibition).
A single drink is probably best, and possible a second if a snack is
involved to help slow down [...]
Pingback by How Does Alcohol Affect Creativity? « Creative
Substances — February 18, 2009 @ 7:05 pm
6.
[...] selection favoring creativity. That is, creative people
tend to attract more partners, and the same genes that confer
heightened creativity can also lead to affective diseases. One
highly publicized study found that professional artists [...]
Pingback by Sex and Creativity « Creative Substances — February
20, 2009 @ 4:45 pm
martes, mayo 04, 2010
Propiedades neurotróficas y neuroprotectoras del Cardo Mariano
En cultivo, el Cardo Mariano (Milk Thristle) aumenta el factor de crecimiento neuronal, induce el crecimiento de las neuritas en las células neuronales PC-12 y prolonga su supervivencia en cultivo.
Neurotrophic and neuroprotective effects of milk thistle (Silybum marianum) on neurons in culture
Smita Kittur1, 3 , Skuntala Wilasrusmee1, Ward A. Pedersen4, Mark. P. Mattson4, Karen Straube-West1, Chumpon Wilasrusmee2, Burk Jubelt1 and Dilip S. Kittur2(1)
Abstract: Herbal products are being increasingly used as dietary supplements and therapeutic agents. However, much more research must be performed in order to determine the biological basis for their putative clinical effects. We tested the effects of milk thistle (Silybum marianum) extract on the differentiation and survival of cultured neural cells. Milk thistle enhanced nerve growth factor (NGF)-induced neurite outgrowth in PC-12 neural cells and prolonged their survival in culture. Milk thistle extract also protected cultured rat hippocampal neurons against oxidative stress-induced cell death. Our data demonstrate that milk thistle extract can promote neuronal differentiation and survival, suggesting potential benefits of chemicals in this plant on the nervous system.
http://www.springerlink.com/content/67670603tj4801h2/
Neurotrophic and neuroprotective effects of milk thistle (Silybum marianum) on neurons in culture
Smita Kittur1, 3 , Skuntala Wilasrusmee1, Ward A. Pedersen4, Mark. P. Mattson4, Karen Straube-West1, Chumpon Wilasrusmee2, Burk Jubelt1 and Dilip S. Kittur2(1)
Abstract: Herbal products are being increasingly used as dietary supplements and therapeutic agents. However, much more research must be performed in order to determine the biological basis for their putative clinical effects. We tested the effects of milk thistle (Silybum marianum) extract on the differentiation and survival of cultured neural cells. Milk thistle enhanced nerve growth factor (NGF)-induced neurite outgrowth in PC-12 neural cells and prolonged their survival in culture. Milk thistle extract also protected cultured rat hippocampal neurons against oxidative stress-induced cell death. Our data demonstrate that milk thistle extract can promote neuronal differentiation and survival, suggesting potential benefits of chemicals in this plant on the nervous system.
http://www.springerlink.com/content/67670603tj4801h2/
jueves, abril 15, 2010
Más sobre la respiración Sudarshan Kriya, dos ejemplos
Cada tanto alguien deja un comentario sobre mis posts sobre la respiración Sudarshan Kriya (El Arte de Vivir). Agradezco porque algunos son buenos, otros no.
Eso me motiva a buscar más información. Es así que encontré esto (el énfasis es mío), una técnica estimulante y otra relajante:
La primera respiración y otros aspectos del curso se pueden ver en este video:
http://www.youtube.com/watch?v=iMdEtJUJodA
Eso me motiva a buscar más información. Es así que encontré esto (el énfasis es mío), una técnica estimulante y otra relajante:
Luis Diego Cob, coordinador de programas e instructor de El Arte de Vivir en México, explicó que el sudarshan kriya es una poderosa técnica de respiración rítmica que colabora con el buen desarrollo físico, mental y emocional.
Su significa poder, darshan significa la visión y kriya es una práctica de purificación. El sudarshan kriya por tanto, es un método realmente purificador mediante el cual uno recibe una adecuada visión de su verdadero ser.
La técnica de respiración de fuelle es también conocida como "café instantáneo natural". Consiste en inhalar y exhalar vigorosamente por la nariz, coordinando un movimiento de brazos.
Con los ojos cerrados, se colocan los brazos doblados y pegados al cuerpo, el dorso de las manos cerca de los hombros. Se suben con fuerza y con las palmas abiertas mientras se inhala una sola vez rápida y vigorosamente. Al exhalar con fuerza por la nariz, se bajan los brazos golpeando levemente las costillas con los codos, quedando en la posición inicial. Se hacen varias repeticiones.
Una técnica de relajación muy buena para antes de dormir consiste en acostarse boca arriba, colocar las manos sobre el abdomen. Inhalar profunda pero suavemente. Exhalar lentamente, presionando un poco con las manos para sacar todo el aire. Repetir varias veces.
La primera respiración y otros aspectos del curso se pueden ver en este video:
http://www.youtube.com/watch?v=iMdEtJUJodA
sábado, marzo 13, 2010
Vuelta a probar Sulbutiamina
Resulta que he vuelto a probar Sulbutiamina. Pueden ver la descripción de Juan Carlos aquí: http://www.drogasinteligentes.com/sulbutiamina.html
Antes no me había resultado mucho pero esta vez le noto un claro efecto estimulante. No son necesarias altas dosis sino más bien esperar unos días.
En Argentina se consigue como Megastene, es de receta pero no hace falta, no está clasificada como psicotrópico. Es medio cara.
La forma de actuar no está clara, parece que modula la dopamina, acetilcolina y glutamato (le tengo desconfianza a este por ser excitotóxico y a los colinérgicos por aumentar la rumiación y el bajo ánimo) en distintas partes del cerebro.
http://en.wikipedia.org/wiki/sulbutiamine
Me parece que me pone un poco nervioso, pero en mí eso es común. para mí el mejor nootrópico sería el que modulara la ansiedad y el ánimo.
Me parece un producto muy interesante, uno se siente más despierto y con más movilidad. Se puede combinar con una toma moderada o baja de café, mate o lo que sea que les dé un poco de cafeína. Esta combinación viene en un producto que se llama Spike de Biotest.
También estoy haciendo un poco de ejercicio, lo cual ayuda. El ejercicio es el mejor nootrópico.
Si alguien tiene experiencia que postee. Gracias.
martes, enero 05, 2010
Elimino los cometarios anónimos?
Blogger, al menos en esta plantilla, no parece tener la opción para poner un comentario usando un nombre y un email. Se puede ingresar un nombre y un URL, pero nomuchos lousan ni tienen uno, me interesa más el email para contactar a la persona si me interesa.
Creo que es bueno poder dejar comentarios anónimos, pero se debería poder poner un email oculto también no?.
Creo que es bueno poder dejar comentarios anónimos, pero se debería poder poner un email oculto también no?.
lunes, noviembre 16, 2009
Medicinas herbales con posible acción antidepresiva
Me interesó esta tabla de Remedios Herbales, sus principios activos y posibles mecanismos de acción que encontré en un PDF:
http://psicofarmacologia.info/curso/antidepresivos.pdf
viernes, noviembre 13, 2009
Aumentar la solubilidad de la cúrcuma
He leído muchos artículos sobre los beneficios de la curcumina, un principio activo en la cúrcuma, el conocido condimento ya mencionado en este blog.
El problema es que la curcumina no se absorve muy bien. Tampoco consigo la curcumina sola sino cúrcuma, la especie en polvo.
Para aumentar la absorción de la curcumina en la cúrcuma estoy haciendo lo siguiente. Como es liposoluble, pongo un poco en un vaso de leche y lo caliento, lo cual también se supone aumenta la solubilidad. Cuando lo retiro agito nuevamente y dejo reposar para que sedimente el exceso y tomo solamente la leche que quedó teñida de un intenso color amarillo-naranja.
No tengo forma de comprobar si lo que hago tiene algún efecto, pero al menos desde la lógica no parece incorrecto.
Si tienen mejores ideas por favor comenten.
El problema es que la curcumina no se absorve muy bien. Tampoco consigo la curcumina sola sino cúrcuma, la especie en polvo.
Para aumentar la absorción de la curcumina en la cúrcuma estoy haciendo lo siguiente. Como es liposoluble, pongo un poco en un vaso de leche y lo caliento, lo cual también se supone aumenta la solubilidad. Cuando lo retiro agito nuevamente y dejo reposar para que sedimente el exceso y tomo solamente la leche que quedó teñida de un intenso color amarillo-naranja.
No tengo forma de comprobar si lo que hago tiene algún efecto, pero al menos desde la lógica no parece incorrecto.
Si tienen mejores ideas por favor comenten.
miércoles, julio 08, 2009
Cúrcuma para la falta de sueño y el estrés crónico
Dos artículos que muestran beneficios de la curcumina que nos pueden interesar salieron en The Durk Pearson & Sandy Shaw® Life Extension News™ August 2009
Chronic Stress: Curcumin Protection in Chronically Stressed Rats
The authors conclude: "These results raise the possibility that increased cell proliferation and neuronal populations may be a mechanism by which curcumin treatment overcomes the stress-induced behavioral abnormalities and hippocampal neuronal damage. Moreover, curcumin treatment, via up-regulation of 5-HT1A receptors and BDNF, may reverse or protect hippocampal neurons from further damage in response to chronic stress, which may underlie the therapeutic actions of curcumin."
http://www.life-enhancement.com/article_template.asp?id=2120
Sleep Deprivation: Curcumin Protects Against Behavioral Alterations and Oxidative Damage in 72 Hour Sleep-Deprived Mice
As the authors explain, "sleep deprivation stimulates hypothalamic-pituitary-adrenal axis resulting in an increased production of corticosterone that leads to cell damage." Excess corticosteroids are known to cause neuronal damage and, hence, impair cognitive function. Curcumin is a powerful scavenger of the superoxide anion, the hydroxyl radical, nitrogen dioxide, and protects against singlet-oxygen-induced DNA strand breaks.1
http://www.life-enhancement.com/article_template.asp?id=2121
El problema con la curcumina es la baja biodisponibilidad (ver http://en.wikipedia.org/wiki/curcumin). Algunos le agregan biperina, la mezclan con aceite, etc. En el último artículo dan la forma que usan (como siempre promocionan su producto):
Chronic Stress: Curcumin Protection in Chronically Stressed Rats
The authors conclude: "These results raise the possibility that increased cell proliferation and neuronal populations may be a mechanism by which curcumin treatment overcomes the stress-induced behavioral abnormalities and hippocampal neuronal damage. Moreover, curcumin treatment, via up-regulation of 5-HT1A receptors and BDNF, may reverse or protect hippocampal neurons from further damage in response to chronic stress, which may underlie the therapeutic actions of curcumin."
http://www.life-enhancement.com/article_template.asp?id=2120
Sleep Deprivation: Curcumin Protects Against Behavioral Alterations and Oxidative Damage in 72 Hour Sleep-Deprived Mice
As the authors explain, "sleep deprivation stimulates hypothalamic-pituitary-adrenal axis resulting in an increased production of corticosterone that leads to cell damage." Excess corticosteroids are known to cause neuronal damage and, hence, impair cognitive function. Curcumin is a powerful scavenger of the superoxide anion, the hydroxyl radical, nitrogen dioxide, and protects against singlet-oxygen-induced DNA strand breaks.1
http://www.life-enhancement.com/article_template.asp?id=2121
El problema con la curcumina es la baja biodisponibilidad (ver http://en.wikipedia.org/wiki/curcumin). Algunos le agregan biperina, la mezclan con aceite, etc. En el último artículo dan la forma que usan (como siempre promocionan su producto):
- The results suggest that, if taking curcumin to help overcome the negative effects of sleep deprivation, take separately from an L-arginine supplement. After a poor night's sleep, we take curcumin the morning after and L-arginine later that day.
- The least expensive way to take curcumin (and a method we use) is to take it as whole ground turmeric root (the spice used in cooking, especially heavily in Indian food). One benefit of this source of curcumin (about 40% of ground turmeric is curcumin) is that it contains, in addition to curcumin, chemically related molecules called curcuminoids that are also beneficial.2,3 We generally take 2 capsules of ground turmeric (each containing 600 mg) 3 or 4 times/day in our Turmeric Root Power™ as well as getting more in our brain maintenance formulation GalantaMind Plus™ capsules (no taste!) If you are taking GalantaMind Plus, you are getting 92.8 mg. curcumin (in 2 capsules/day) or 139.2 mg curcumin (in 3 capsules/day) from turmeric root powder.
- The least expensive way to take curcumin (and a method we use) is to take it as whole ground turmeric root (the spice used in cooking, especially heavily in Indian food). One benefit of this source of curcumin (about 40% of ground turmeric is curcumin) is that it contains, in addition to curcumin, chemically related molecules called curcuminoids that are also beneficial.2,3 We generally take 2 capsules of ground turmeric (each containing 600 mg) 3 or 4 times/day in our Turmeric Root Power™ as well as getting more in our brain maintenance formulation GalantaMind Plus™ capsules (no taste!) If you are taking GalantaMind Plus, you are getting 92.8 mg. curcumin (in 2 capsules/day) or 139.2 mg curcumin (in 3 capsules/day) from turmeric root powder.
domingo, junio 21, 2009
Posteando nuevamente
Como varias veces antes, tuve problemas con Blogger.
Creo que ahora anda y estuve enviando un par de mensajes que fueron al grupo de discusión por no poder ponerlos acá.
Hasta pronto.
Creo que ahora anda y estuve enviando un par de mensajes que fueron al grupo de discusión por no poder ponerlos acá.
Hasta pronto.
Ojo con el Hiperico
El Hipérico es cada vez más conocido, pero no sé si tanto se conoce que
produce disminución de los niveles de muchas drogas (entiendo por esto
cualquier molécula incluso medicinal) por interactuar con el citocromo
P450. Lo cual lo hace prácticamente poco usable.
Ver http://www.aeii.org/articulo/hyperi1.htm
Una forma de saber posibles interacciones entre drogas (o alimentos,
moléculas al final) es buscar cómo se metabolizan, por ejemplo poner en un
buscador: droga citocromo P450 (o el que sea).
Como ejemplo, acabo de ver que el hipérico afectaría las concentraciones de
T4, la hormona de reemplazo tiroidea que mucha gente toma.
Esta página que acabo de encontrar trae muy buena información molecular
http://www.drugbank.ca/
produce disminución de los niveles de muchas drogas (entiendo por esto
cualquier molécula incluso medicinal) por interactuar con el citocromo
P450. Lo cual lo hace prácticamente poco usable.
Ver http://www.aeii.org/articulo/hyperi1.htm
Una forma de saber posibles interacciones entre drogas (o alimentos,
moléculas al final) es buscar cómo se metabolizan, por ejemplo poner en un
buscador: droga citocromo P450 (o el que sea).
Como ejemplo, acabo de ver que el hipérico afectaría las concentraciones de
T4, la hormona de reemplazo tiroidea que mucha gente toma.
Esta página que acabo de encontrar trae muy buena información molecular
http://www.drugbank.ca/
Suplementar con vit E alfa baja la gama
Nuevos estudios muestran el problema de suplementar con una sola forma de
la vitamina E. Si se administra alfa tocoferol, la forma gama, que tiene
importanets funciones, baja dependiendo de la dosis.
The gamma form of vitamin E demonstrates several superior properties (such
as trapping reactive nitrogen species and detoxifying nitrogen dioxide)
compared with alpha vitamin E.
...
The results demonstrate that alpha vitamin E levels increased in proportion
to the dose administered. However, at every dose of alpha vitamin E, gamma
vitamin E concentration was significantly suppressed. No beneficial changes
in surrogate markers of atherosclerosis were observed, consistent with the
negative results of prospective clinical trials using alpha vitamin E
http://pmid.us/19303966
la vitamina E. Si se administra alfa tocoferol, la forma gama, que tiene
importanets funciones, baja dependiendo de la dosis.
The gamma form of vitamin E demonstrates several superior properties (such
as trapping reactive nitrogen species and detoxifying nitrogen dioxide)
compared with alpha vitamin E.
...
The results demonstrate that alpha vitamin E levels increased in proportion
to the dose administered. However, at every dose of alpha vitamin E, gamma
vitamin E concentration was significantly suppressed. No beneficial changes
in surrogate markers of atherosclerosis were observed, consistent with the
negative results of prospective clinical trials using alpha vitamin E
http://pmid.us/19303966
Las dosis más bajas de alfa tocoferol usadas en el estudio (con paciente d
ediabetes mellitus tipo 2) fueron de 200 IU.
Esto es un lío. Había leído otros artículos pero no los tengo a mano.
Habría que ver qué discusiones se arman en la red.
¿Comentarios?.
domingo, febrero 08, 2009
Probando citrato de magnesio
He leído muchas cosas buenas sobre la suplementación con magnesio. Las recomendaciones van desde los calambres, el stress hasta la depresión.
El problema con el magnesio es el tipo de sal. Hay mucho debate sobre cuál es la sal más adecuada (biodisponible).
Si se quiere una acción no estimulante supongo que los aspartatos quedan de lado.
Terminé comprando citrato de magnesio. Un poco porque me recuerda que el famoso deprenyl liquido es citrato y se supone que es más biodisponible que la fórmula en tabletas que creo es clorhidrato. En un escrito de Discovery, los fabricantes originales del deprenyl líquido se decía que el citrato facilita el pasaje al cerebro. ¿Será posible que el citrato de magnesio llegue más al cerebro aportando más magnesio a las neuronas y modulando su funcionamiento?. Pura especulación.
Como el citrato es caro (compré Total Magnesiano grageas por 30 a 33 pesos y monedas con descuento) si no veo gran diferencia creo que voy a volver al cloruro de magnesio que tiene un gusto feo pero es económico. En farmacias lo venden fraccionado y en las droguerías se consigue en cantidad a bajo precio. Lo he comprado alguna vez en una droguería industrial, supongo que la pureza no será tan mala.
Si tienen comentarios por favor dejen su opinión o únanse al grupo de discusión sobre Nootrópicos
El problema con el magnesio es el tipo de sal. Hay mucho debate sobre cuál es la sal más adecuada (biodisponible).
Si se quiere una acción no estimulante supongo que los aspartatos quedan de lado.
Terminé comprando citrato de magnesio. Un poco porque me recuerda que el famoso deprenyl liquido es citrato y se supone que es más biodisponible que la fórmula en tabletas que creo es clorhidrato. En un escrito de Discovery, los fabricantes originales del deprenyl líquido se decía que el citrato facilita el pasaje al cerebro. ¿Será posible que el citrato de magnesio llegue más al cerebro aportando más magnesio a las neuronas y modulando su funcionamiento?. Pura especulación.
Como el citrato es caro (compré Total Magnesiano grageas por 30 a 33 pesos y monedas con descuento) si no veo gran diferencia creo que voy a volver al cloruro de magnesio que tiene un gusto feo pero es económico. En farmacias lo venden fraccionado y en las droguerías se consigue en cantidad a bajo precio. Lo he comprado alguna vez en una droguería industrial, supongo que la pureza no será tan mala.
Si tienen comentarios por favor dejen su opinión o únanse al grupo de discusión sobre Nootrópicos
miércoles, enero 28, 2009
B3 mejora el Alzheimer
La vitamina B3 muestra efectividad en reducir los déficits cognitivos en la enfermedad de Alzheimer.
- NEW YORK (Reuters Health) Nov 19 - Nicotinamide reverses the cognitive
- deficits in a transgenic mouse model of Alzheimer's disease, according to a
- new report.
- Nicotinamide administered for 4 months beginning at 4 months of age
- prevented cognitive deficits and improved short-term spatial memory in the
- 3xTg-AD mice, the authors report in the November 5th issue of The Journal
- of Neuroscience.
- Nicotinamide did not appear to alter the production of amyloid-beta, but
- did reduce the steady state levels of Thr231 phosphorylated tau, which is
- associated with microtubule depolymerization.
- Treatment with nicotinamide also upregulated proteins associated with
- increased microtubule stabilization and upregulated p25, which is linked to
- improved learning and memory, the investigators say.
- http://medgenmed.medscape.com/viewarticle/583878_print
- deficits in a transgenic mouse model of Alzheimer's disease, according to a
martes, enero 27, 2009
Nuevos posts
Ahora que Blogger comenzó a andar como parece que debiera voy a poder actualizar y recuperar posts.
Acualicé los posts pero veo que quedaron con la fecha original. No sé qué es peor.
En todo caso lean para abajo desde este aviso y los encontrarán.
Los títulos son éstos:
Blogger no anda bien 24/03/08
El misterio del Sudarshan Kriya de Ravi Shankar 10/03/08
Nootropics - Past, Present, and Future powerpoint 26/02/08
PBS Special "Change Your Brain, Change Your Life" ... 26/02/08
Omega 3 y aspirina contra el dolor y la inflamacio... 23/02/08
Cómo estudiar para rendir con éxito los exámenes 11/02/08
Comer bananas 8/02/08
Correlacion entre velocidad al caminar y del pensa... 26/01/08
Disculpen las molestian y gracias.
Acualicé los posts pero veo que quedaron con la fecha original. No sé qué es peor.
En todo caso lean para abajo desde este aviso y los encontrarán.
Los títulos son éstos:
Blogger no anda bien 24/03/08
El misterio del Sudarshan Kriya de Ravi Shankar 10/03/08
Nootropics - Past, Present, and Future powerpoint 26/02/08
PBS Special "Change Your Brain, Change Your Life" ... 26/02/08
Omega 3 y aspirina contra el dolor y la inflamacio... 23/02/08
Cómo estudiar para rendir con éxito los exámenes 11/02/08
Comer bananas 8/02/08
Correlacion entre velocidad al caminar y del pensa... 26/01/08
Disculpen las molestian y gracias.
viernes, julio 18, 2008
miércoles, abril 30, 2008
Google apesta
Estoy harto de Blogger. Google se extiende, compra cosas pero no las hace funcionar.
Hace meses que no puedo postear porque las funcionalidades de este blog no están activas. Es lento, se pierde tiempo y te arrepentís de haber confiado.
Les sugiero que si quieren seguir los temas se suscriban a la lista de discusión en Nootrópicos en Yahoo! Grupos
¡Estoy enojado!.
Hace meses que no puedo postear porque las funcionalidades de este blog no están activas. Es lento, se pierde tiempo y te arrepentís de haber confiado.
Les sugiero que si quieren seguir los temas se suscriban a la lista de discusión en Nootrópicos en Yahoo! Grupos
¡Estoy enojado!.
lunes, abril 28, 2008
lunes, marzo 24, 2008
lunes, marzo 10, 2008
El misterio del Sudarshan Kriya de Ravi Shankar
Me llama la atención que de tanto en tanto alguien deja un comentario en mi post "Como realizar la respiración Sudarshan Kriya de Ravi Shankar" diciendo que hicieron el curso y que no es así tal cual se explica.
Les agradezco, pero no entiendo por qué no comentan en el blog o en nuestra lista de discusión sobre Nootrópicos cómo es realmente. Pareciera que es algo que se desea mantener oculto. Como ya dije en los comentarios el conocimiento se escribe y se comenta, sino es argumento de venta. Por publicar un conocimiento no se arruina, al contrario, se enriquece y además no crea competencia porque sino todos seríamos cirujanos con tal de leer un librito y no es así. A qué se teme?. ¿Es liberadora una enseñanza que promueve el ocultamiento y el egoísmo (y el negocio porque el curso es caro)?.
Me gustaría saber más sobre Sudarshan Kriya y sobre otras formas de meditación como el Zen.
Les agradezco, pero no entiendo por qué no comentan en el blog o en nuestra lista de discusión sobre Nootrópicos cómo es realmente. Pareciera que es algo que se desea mantener oculto. Como ya dije en los comentarios el conocimiento se escribe y se comenta, sino es argumento de venta. Por publicar un conocimiento no se arruina, al contrario, se enriquece y además no crea competencia porque sino todos seríamos cirujanos con tal de leer un librito y no es así. A qué se teme?. ¿Es liberadora una enseñanza que promueve el ocultamiento y el egoísmo (y el negocio porque el curso es caro)?.
Me gustaría saber más sobre Sudarshan Kriya y sobre otras formas de meditación como el Zen.
martes, febrero 26, 2008
Nootropics - Past, Present, and Future powerpoint
Nootropics - Past, Present, and Future una presentación en powerpoint por Will Block
- On Wed., January 16th, 2006, Will Block gave a lecture to the Silicon Valley Transhumanist Meetup Group titled "Nootropics, Past, Present & Future." The discussion was quite interesting and was followed by extensive questions and answers.
PBS Special "Change Your Brain, Change Your Life" Dr. Amen
- We are providing the links below for you to view the full PBS Special "Change Your Brain, Change Your Life."( If you find the video playing slowly from your link please try another as demand for the video varies from server to server).
- http://amenclinics.com/server1
- http://amenclinics.com/server2
- http://amenclinics.com/server3
- http://amenclinics.com/server1
Edit 2009: parece que estos videos no se encuantran disponibles ya.
domingo, febrero 24, 2008
Omega 3 y aspirina contra el dolor y la inflamacion
Para el alivio del dolor en procesos inflamatorios como la artritis se puede probar una combinación de Omega 3 y aspirina antes de acostarse. Esto parece bueno también para procesos inflamatorios neurológicos como el Alzheimer.
- ...aspirin, a partial inhibitor of the COX-2 enzyme, can largely convert this enzyme to a machine that prefers acting on the omega 3 fats
- ...
- For relief of pain such as that associated with arthritis, you might want to try ½ aspirin (160mg) along with an extra dose of the supplement of DHA/EPA before bed time, but be sure first to consult with your physician.
- ...
lunes, febrero 11, 2008
Cómo estudiar para rendir con éxito los exámenes
Basados en investigaciones psicológicas estos son unos consejos para estudiar más efectivamente (a pesar de parecer contra lo que se supone debe hacerse), por Dr. Nate Kornell (UCLA):
Espaciar el estudio. En vez de sesiones maratónicas y noches en vela, conviene repartir el material de estudio, por ejemplo un día estudiar un capítulo o lo que sea y otro día repasar.
Hacerse preguntas. Preguntarse y examinarse a sí mismo crea memorias poderosas. Además permite diagnosticarse y corregirse antes del examen. Pero el secreto es no testearse inmediatamente después de estudiar cuando la memoria está fresca, hay que hacerlo después de un tiempo.
Resumir e integrar. Después de ir a clase o estudiar un capítulo conviene resumir los puntos principales. Este proceso conocido como integración del conocimiento crea una memoria duradera de lo estudiado y tiene el beneficio de obligarte a recordar el material (para resumirlo). Una forma de aplicar esto es aprender enseñando, es decir contarles a otros lo que aprendimos. Explicar requiere capacidad de resumir y de integrar y además permite advertir los propios fallos y deficiencias.
Ver más en Inglés en How to study en bps-research-digest.blogspot.com
Espaciar el estudio. En vez de sesiones maratónicas y noches en vela, conviene repartir el material de estudio, por ejemplo un día estudiar un capítulo o lo que sea y otro día repasar.
Hacerse preguntas. Preguntarse y examinarse a sí mismo crea memorias poderosas. Además permite diagnosticarse y corregirse antes del examen. Pero el secreto es no testearse inmediatamente después de estudiar cuando la memoria está fresca, hay que hacerlo después de un tiempo.
Resumir e integrar. Después de ir a clase o estudiar un capítulo conviene resumir los puntos principales. Este proceso conocido como integración del conocimiento crea una memoria duradera de lo estudiado y tiene el beneficio de obligarte a recordar el material (para resumirlo). Una forma de aplicar esto es aprender enseñando, es decir contarles a otros lo que aprendimos. Explicar requiere capacidad de resumir y de integrar y además permite advertir los propios fallos y deficiencias.
Ver más en Inglés en How to study en bps-research-digest.blogspot.com
viernes, febrero 08, 2008
Comer bananas
- Brain Power : The banana has proven to boost brain power. 200 students at a Twickenham (middlesex) school were helped through their exams by eating bananas at breakfast, break and lunch in a bid to boost their brain power. Research has shown that the potassium-packed fruit can assist learning by making pupils more alert.
sábado, enero 26, 2008
Correlacion entre velocidad al caminar y del pensamiento
Parece que la velocidad con que caminan los ancianos es un indicador del rendimiento mental.
- Among the elderly, slower walkers have slower brains
- Older people who walk more slowly also perform less well on tests of mental performance - an association researchers say could prove useful for diagnosis and therapeutic interventions.
- Older people who walk more slowly also perform less well on tests of mental performance - an association researchers say could prove useful for diagnosis and therapeutic interventions.
lunes, enero 14, 2008
Vitaminas B para preservar la memoria
Según un estudio dosis adecuadas de viaminas del grupo B (vean que no son exageradas, especialmente la B6 que ya vimos puede dar problemas en megadosis, sí es alto el ácido fólico) disminuyen la presencia de proteína beta amiloide en la circulación sanguínea, un indicador de senilidad.
El mismo autor reporta otra buena cualidad del ácido fólico, reducir el riesgo del virus del papiloma humano.
- Can a person maintain good memory and recall for 115 years? A recent report published in the journal Neurobiology of Aging, documents the case of a 115-year old woman with remarkable preservation of her mental faculties. A more recent report in the same journal points to a simple array of B vitamins (25 mg vitamin B6/pyridoxine, 2000 mcg vitamin B9/folic acid, 400 mcg vitamin B12) which dramatically decreased levels of beta-amyloid in the blood circulation. Beta amyloid is the plaque that builds up in the brain with advancing age that is implicated in Alzheimer's disease. After two years on vitamin therapy, blood levels of beta amyloid only increased by 4.9%, compared to 18.5% in a group received an inactive placebo tablet. Elevated blood levels of beta amyloid is an indicator of the onset of senility. [Neurobiology of Aging 29: 303-06, 2008]
El mismo autor reporta otra buena cualidad del ácido fólico, reducir el riesgo del virus del papiloma humano.
- Women with high folic acid levels exhibit a 73% reduced risk for the Human papilloma virus. [Cancer Research 2004; 64: 8788]
viernes, enero 11, 2008
Hiperico contra el Alzheimer
- La milenaria yerba de San Juan, también conocida por "liberar los malos espíritus" en la época de la Inquisición, atrae una vez más a los científicos. Uno de sus 10 compuestos activos, la hiperforina, el mismo que tiene el efecto antidepresivo, promete prevenir y tratar el alzheimer.
miércoles, enero 09, 2008
4 factores que agregan 14 años de vida
Un estudio en el Reino Unido de 25.000 personas demostró que las que no cumplen con las siguientes pautas mueren en promedio 14 años antes que los que las siguen:
- * no fumar
- * comer suficientres frutas y verduras
- * hacer ejercicio
- * beber moderadamente
- * comer suficientres frutas y verduras
miércoles, diciembre 26, 2007
Bloguean sorbe el uso de drogas para mejorar el rendimiento mental
Cada vez más los weblogs se hacen eco del tema, principalmente en USA donde hay mucha competencia y medicalización de estos problemas:
Nature article 'Professor's little helper'.
Nature forum 'Would you boost your brain power?'.
via mindhacks.com
Cognitive Enhancers in Academic Doping
Nature article 'Professor's little helper'.
Nature forum 'Would you boost your brain power?'.
via mindhacks.com
Cognitive Enhancers in Academic Doping
viernes, diciembre 14, 2007
La pasionaria es buena para la ansiedad
La pasionaria (passiflora incarnata, passion flower, passiflower) es una buena hierba para la ansiedad leve. No produce somnolencia y actúa bastante rápido.
Es una buena opción para quienes necesitan controlar el estrés o la ansiedad y mejorar el ánimo.
La estuve probando y me gustó. La forma en que prefiero tomarla es en gotas, así controlo la dosis. Se vende en farmacias o dietéticas como extracto o tintura. La tintura es casi 5 veces más concentrada y se nota por su color más oscuro.
Es una buena opción para quienes necesitan controlar el estrés o la ansiedad y mejorar el ánimo.
La estuve probando y me gustó. La forma en que prefiero tomarla es en gotas, así controlo la dosis. Se vende en farmacias o dietéticas como extracto o tintura. La tintura es casi 5 veces más concentrada y se nota por su color más oscuro.
sábado, noviembre 10, 2007
El ejercicio mejora la funcion ejecutiva del cerebro
"In humans, exercise improves what scientists call "executive function," the set of abilities that allows you to select behavior that's appropriate to the situation, inhibit inappropriate behavior and focus on the job at hand in spite of distractions. Executive function includes basic functions like processing speed, response speed, and working memory, the type used to remember a house number while walking from the car to a party."
Exercise on the Brain [NYT]
Exercise on the Brain [NYT]
lunes, octubre 08, 2007
Los consejos de Hyla Cass para mejorar la capacidad mental
Top Tips for Natural Mind Enhancement
If your razor-sharp intellect is blunted and your memory is failing you, here's what to do for that extra mental edge:
Take a B complex supplement that provides 50 mg each of vitamins B3, B5, B6, 50 mcg of B12 and 400 mg of folic acid (in addition to what's in your multivitamin); also take 1,000 mg of DHA/EPA or eat fish three times a week.
Your mind-boosting formula can contain any or all of the following. Experiment with the individual products to get your own special mix.
Start with 60 mg of ginkgo
add in 200 mg of phosphatidyl choline
200 mg of DMAE
10 mg of vinpocetine
and 50 mg of phosphatidyl serine. These doses are acceptable in a combined formula, but again, use your own response as the measure.
Other Tips:
Do some aerobic exercise to oxygenate your brain, raise endorphins, and as an added bonus, burn some fat.
Take a bath with essential oils of lemon, eucalyptus, cinnamon or peppermint dispersed in the water, or scent your room with them.
Listen to stimulating music.
Maximize the light in your room with natural daylight or full-spectrum lighting.
Por Hyla Cass, que no sé cuanta credibilidad tiene pero no parece mal orientado. Hay otros consejos (stress, energía, ánimo) en la nota Top tips for natural highs.
En realidad que las vitaminas B sean todas en 50 mg es algo infundado y más bien porque es así como se venden.
If your razor-sharp intellect is blunted and your memory is failing you, here's what to do for that extra mental edge:
Take a B complex supplement that provides 50 mg each of vitamins B3, B5, B6, 50 mcg of B12 and 400 mg of folic acid (in addition to what's in your multivitamin); also take 1,000 mg of DHA/EPA or eat fish three times a week.
Your mind-boosting formula can contain any or all of the following. Experiment with the individual products to get your own special mix.
Start with 60 mg of ginkgo
add in 200 mg of phosphatidyl choline
200 mg of DMAE
10 mg of vinpocetine
and 50 mg of phosphatidyl serine. These doses are acceptable in a combined formula, but again, use your own response as the measure.
Other Tips:
Do some aerobic exercise to oxygenate your brain, raise endorphins, and as an added bonus, burn some fat.
Take a bath with essential oils of lemon, eucalyptus, cinnamon or peppermint dispersed in the water, or scent your room with them.
Listen to stimulating music.
Maximize the light in your room with natural daylight or full-spectrum lighting.
Por Hyla Cass, que no sé cuanta credibilidad tiene pero no parece mal orientado. Hay otros consejos (stress, energía, ánimo) en la nota Top tips for natural highs.
En realidad que las vitaminas B sean todas en 50 mg es algo infundado y más bien porque es así como se venden.
sábado, octubre 06, 2007
Hoy estaba acelerado y era por la hydergina
Hoy a la mañana estaba bastante acelarado y quería hacer cosas y rápido
pero tenía un poco de ansiedad.
pero tenía un poco de ansiedad.
No entendía bien qué pasaba, hasta que me acordé de que había tomado 2,25
mg de hydergina que hacía mucho que no tomaba. Casi seguro que esa fue la
causa.
Por lo tanto voy a tomar la mitad de la dosis la próxima vez.
domingo, septiembre 23, 2007
Rhodiola ayuda en la depresion y a estudiantes
Parece que sigue el interés en la hierba Rhodiola como adaptógeno, mejorador del ánimo y de la agilidad mental.
Yo la he probado pero no de una marca reconocida. No noté un claro efecto. Recomiendo, si pueden, comprar la del Swedish Herbal Institut o alguna que tenga respaldo.
La buena noticia es que según el artículo en Canadá se está cultivando en la provincia de Alberta. Puede ser que tengamos un producto accesible y de buena calidad.
Meanwhile, Wikman and the Swedish Herbal Institute, which makes a rhodiola
extract called SHR-5, have continued laboratory and human tests. In 2000,
they reported that SHR-5 protects snail embryos from heat, copper, and
oxidative stress. When given the herb extract, fewer of the embryos died
after exposure to these stressors than did embryos not given the extract.
Also in 2000, Wikman and his colleagues in Russia published results from a
randomized, double-blind trial of university students who took SHR-5 at the
end of a semester. Students taking the herb for 20 days fared better on
measures of fatigue and mental performance than did students who took a
placebo. Another study published in 2000 found an antifatigue effect of the
herb among 56 physicians working night shifts.
sciencenews.org
Yo la he probado pero no de una marca reconocida. No noté un claro efecto. Recomiendo, si pueden, comprar la del Swedish Herbal Institut o alguna que tenga respaldo.
La buena noticia es que según el artículo en Canadá se está cultivando en la provincia de Alberta. Puede ser que tengamos un producto accesible y de buena calidad.
Meanwhile, Wikman and the Swedish Herbal Institute, which makes a rhodiola
extract called SHR-5, have continued laboratory and human tests. In 2000,
they reported that SHR-5 protects snail embryos from heat, copper, and
oxidative stress. When given the herb extract, fewer of the embryos died
after exposure to these stressors than did embryos not given the extract.
Also in 2000, Wikman and his colleagues in Russia published results from a
randomized, double-blind trial of university students who took SHR-5 at the
end of a semester. Students taking the herb for 20 days fared better on
measures of fatigue and mental performance than did students who took a
placebo. Another study published in 2000 found an antifatigue effect of the
herb among 56 physicians working night shifts.
sciencenews.org
domingo, septiembre 09, 2007
Conviene distribuir el estudio en el tiempo
Estudiar en grandes bloques no ayuda al aprendizaje a largo plazo. Conviene hacerlo por partes y repasar, es decir distribuir el estudio en el tiempo.
In other words, as reported in the August issue of Current Directions in Psychological Science, �massing� all the study on a single topic into a single session reduces long-term retention. It�s better to leave it alone for a while and then return to it. Rohrer and Pashler also wanted to see if the duration of study breaks might make a difference in learning. It did. When two study sessions were separated by breaks ranging from five minutes to six months, with a final test given six months later, students did much better if their break lasted at least a month. So, rather than distribute their study of some material across just a few days, as millions of school children do when given a different list of vocabulary or spelling words each week, students would be better off seeing the same words throughout the school year.
futurepundit.com
In other words, as reported in the August issue of Current Directions in Psychological Science, �massing� all the study on a single topic into a single session reduces long-term retention. It�s better to leave it alone for a while and then return to it. Rohrer and Pashler also wanted to see if the duration of study breaks might make a difference in learning. It did. When two study sessions were separated by breaks ranging from five minutes to six months, with a final test given six months later, students did much better if their break lasted at least a month. So, rather than distribute their study of some material across just a few days, as millions of school children do when given a different list of vocabulary or spelling words each week, students would be better off seeing the same words throughout the school year.
futurepundit.com
sábado, julio 21, 2007
Vuelve el uso de LSD en psicoterapias
The Royal Society of Chemistry reports that a research project investigating the potential benefits of LSD assisted psychotherapy for people with terminal illnesses has been given the go-ahead by the Swiss authorities.
mindhacks.com
mindhacks.com
jueves, julio 19, 2007
Anoche tome hydergina, hoy mi combo y voy mejor
Ayer tenía que escribir un trabajo pero no podía, la magnitud de la tarea
me tenía mal (sumado a preocupaciones personales de otro tipo).
me tenía mal (sumado a preocupaciones personales de otro tipo).
Tomé en forma sublingual una última dosis de hydergina de 1.5 mg que tenía.
Sentí algún pequeño efecto. Igual no pude trabajar.
Al irme a dormir me sentía todavía alerta. Tomé una pequeña dosis de
ansiolítico (benzodiacepina), ojo esto no es para jugar, pero lo comento
porque puede tener que ver con el efecto final. Dormí bastante bien, me
pregunto qué habrá tenido que ver en esto la hydergina.
Al despertarme hoy bastante temprano (hay buen sol y eso ayuda a despertar
y al ánimo) y antes de desayunar tomé en ayunas dosis normales de DMAE (lo
vengo tomando hace unos días a este controvertido suplemento), TMG,
piracetam, un poco de cinc y tomé mate cocido con una pizca de ginseng rojo
y jengibre. Después un vaso de leche, no tenía mucha hambre pero hay que
aportar algo de proteínas.
Como resultado me siento mejor (a pesar de que tengo los mismos problemas)
y ahora estoy escribiendo com mayor facilidad. Incluso tipeo mejor. No
quiero agrandar la cosa ni promover el uso de nada, solamente reportar para
mi propio control y que ustedes comenten.
Lo único diferente que agregué a mi dieta ayer fueron semillas de lino
molidas para agregar omega 3 (que se sabe son buenos para el cerebro pero
esto es una dosis baja) y otros nutrientes.
Si tienen éxito con algún suplemento que los ayude sobre todo en tareas de
estudio y escritura me interesa.
Un producto del que quisiera tener más conocimiento por experiencias es la
hupericina (huperzia, Huperzine A).
miércoles, julio 18, 2007
Alguien experimento con hupericina?
No encuentro muchos reportes sobre el uso de hupericina (huperzia serrata, hupericine).
Además de inhibir la degradación de la acetilcolina tiene otras propiedades, pero no sé si en una persona que no tenga graves problemas funciona bien. He visto algunos estudios en jóvenes estudiantes que parecen indicar efectividad o reportes de mayor concentración, pero no muchos coemntarios en foros.
Si alguien quiere comentar sería interesante.
Además de inhibir la degradación de la acetilcolina tiene otras propiedades, pero no sé si en una persona que no tenga graves problemas funciona bien. He visto algunos estudios en jóvenes estudiantes que parecen indicar efectividad o reportes de mayor concentración, pero no muchos coemntarios en foros.
Si alguien quiere comentar sería interesante.
lunes, julio 09, 2007
Recordatorio sobre nuestra lista de discusion
Si existe alguien que lea esto y además se interesa en el tema, lo animo a que deje comentarios si los tiene (puede hacerlo en forma anónima) y que se una a nuestra lista de discusión en Yahoo! Grupos.
Las discusiones se pueden seguir por email o mediante la página web.
Allí podemos tratar temas en forma más privada y responder preguntas prácticas. Ya somos unos cuantos.
Las discusiones se pueden seguir por email o mediante la página web.
Allí podemos tratar temas en forma más privada y responder preguntas prácticas. Ya somos unos cuantos.
domingo, julio 01, 2007
La importancia de las proteinas en el desayuno
En un estudio se vió que el hábito de algunos estudiantes de incluir jamón y queso en el desayuno los ayudaba en el rendimiento escolar.
El buen efecto se atribuye a que un desayuno rico en proteínas produce una liberación más lenta de glucosa.
Report: Ideal breakfast has ham, cheese
LONDON, June 24 (UPI) -- A scientific study of British students' eating habits has found eating ham and cheese for breakfast can significantly improve cognitive functioning.
...
"It is all down to the glucose release of the breakfast into the bloodstream. The slower the release, the better the pupils performed," Benton said of his study's findings.
...
"The high protein in the breakfast will release into the system slowly, and therefore it will suppress the appetite for longer, and prevent children from snacking," he told the newspaper.
sciencedaily.com
El buen efecto se atribuye a que un desayuno rico en proteínas produce una liberación más lenta de glucosa.
Report: Ideal breakfast has ham, cheese
LONDON, June 24 (UPI) -- A scientific study of British students' eating habits has found eating ham and cheese for breakfast can significantly improve cognitive functioning.
...
"It is all down to the glucose release of the breakfast into the bloodstream. The slower the release, the better the pupils performed," Benton said of his study's findings.
...
"The high protein in the breakfast will release into the system slowly, and therefore it will suppress the appetite for longer, and prevent children from snacking," he told the newspaper.
sciencedaily.com
miércoles, junio 27, 2007
Merk nutrition y Office of Dietary Supplements NIH
Buenos sitios de referencia en nutrición y suplementos dietarios:
Merk Nutrition: General Considerations
Office of Dietary Supplements • NIH Clinical Center • National Institutes of Health
Merk Nutrition: General Considerations
Office of Dietary Supplements • NIH Clinical Center • National Institutes of Health
miércoles, junio 20, 2007
Rehabilitacion Biomecanica Avanzada del trauma cerebral
Leyendo el diario me enteré de esta técnica que no conocía.
"Advanced Biomechanical Rehabilitation" cuya
traducción al castellano es: Rehabilitación Biomecánica Avanzada.
• ABR es el único método de rehabilitación basado en la biomecánica
que proporciona una recuperación de la estructura músculo-esquelética
y funciones motoras a niños y jóvenes adultos con daño cerebral.
http://www.abrtherapy.com.ar
"Advanced Biomechanical Rehabilitation" cuya
traducción al castellano es: Rehabilitación Biomecánica Avanzada.
• ABR es el único método de rehabilitación basado en la biomecánica
que proporciona una recuperación de la estructura músculo-esquelética
y funciones motoras a niños y jóvenes adultos con daño cerebral.
http://www.abrtherapy.com.ar
martes, junio 12, 2007
La Isradipina de uso en hipertension frenaria el parkinson
La Isradipina, una droga conocida y de uso en Argentina (DYNACIRC SRO NOVARTIS
Calcioantagonista Antihipertensivo ) frena el parkinson en un modelo de la enfermedad en ratones.
Explicado sencillamente y sin mayores exactitudes el mecanismo protector consiste en que la isradipina bloquea los canales de calcio y así hace que la neurona deteriorada que produce dopamina (son limitadas y tienden a morir especialmente en el parkinson) deje de usar calcio para activar su funcionamiento y vuelva a usar sodio como una neurona sana y joven.
La droga podría también beneficiar al hacer necesario menor dosis de medicaciones como la L-DOPA y mantenerla eficaz y no tener que usar cada vez dosis mayores como les pasa a los pacientes de parkinson.
Se habla también del posible uso preventivo y terapéutico en parkinson.
Drug slows and may halt Parkinson's disease
CHICAGO -- Northwestern University researchers have discovered a drug that slows – and may even halt – the progression of Parkinson's disease. The drug rejuvenates aging dopamine cells, whose death in the brain causes the symptoms of this devastating and widespread disease.
...
Dopamine is a critical chemical messenger in the brain that affects a person's ability to direct his movements. In Parkinson's disease, the neurons that release dopamine die, causing movement to become more and more difficult.
...
"Our hope is that this drug will protect dopamine neurons, so that if you began taking it early enough, you won't get Parkinson's disease, even if you were at risk. " said Surmeier, who heads the Morris K. Udall Center of Excellence for Parkinson's Disease Research at Northwestern. "It would be like taking a baby aspirin everyday to protect your heart."
Isradipine may also significantly benefit people who already have Parkinson's disease. In animal models of the disease, Surmeier's team found the drug protected dopamine neurons from toxins that would normally kill them by restoring the neurons to a younger state in which they are less vulnerable.
The principal therapy for Parkinson's disease patients currently is L-DOPA, which is converted in the brain to dopamine. Although L-DOPA relieves many symptoms of the disease in its early stages, the drug becomes less effective over time. As the disease progresses, higher doses of L-DOPA are required to help patients, leading to unwanted side-effects that include involuntary movements. The hope is that by slowing the death of dopamine neurons, isradipine could significantly extend the time in which L-DOPA works effectively.
"If we could double or triple the therapeutic window for L-DOPA, it would be a huge advance," Surmeier said.
...
Because he's a physiologist, Surmeier decided to investigate whether the electrical activity of dopamine neurons might provide a clue to their vulnerability. All neurons in the brain use electrical signals to do their job, much like digital computers.
First, Surmeier observed that dopamine neurons are non-stop workers called pacemakers. They generate regular electrical signals seven days a week, 24 hours a day, just like pacemaker cells in the heart. This was already known. But then he probed more deeply and discovered something very strange about these dopamine neurons.
Most pacemaking neurons use sodium ions (like those found in table salt) to produce electrical signals. But Surmeier found that adult dopamine neurons use calcium instead.
Sodium is a mild mannered ion that does its job without causing a whit of trouble to the cell. Calcium ions, however, are wild and rambunctious.
...
"The reliance upon calcium was a red flag to us," Surmeier said. Calcium ions need to be chaperoned by the cell almost as soon as they enter to keep them from causing trouble, he noted. The cell has to sequester them or keep pumping them out. This takes a lot of energy.
...
Surmeier theorized that the non-stop stress on the dopamine neurons explains why they are more vulnerable to toxins and die at a more rapid rate as we age.
...
When the neurons are young, Surmeier found they actually use sodium ions to do their work. But as the neurons age, they become more and more dependent on the troublesome calcium and stop using sodium. This calcium dependence – and the stress it causes the neurons --is what makes them more vulnerable to death.
What would happen, Surmeier wondered, if he simply blocked the calcium's route into the adult neuron cells" Would the neurons revert to their youthful behavior and start using sodium again"
"The cells had put away their old childhood tools in the closet. The question was if we stopped them from behaving like adults would they go into the closet and get them out again"" Surmeier asked. "Sure enough, they did."
When he gave the mice isradipine, it blocked the calcium from entering the dopamine neuron. At first, the dopamine neurons became silent. But within a few hours, they had reverted to their childhood ways, once again using sodium to get their work done.
"This lowers the cells' stress level and makes them much more resistant to any other insult that's going to come along down the road. They start acting like they're youngsters again," Surmeier said.
The next step will be launching a clinical study.
"This animal study suggests that calcium channel blockers, drugs currently used to reduce blood pressure, might someday be used to slow the steady progression of Parkinson's disease," said Walter J. Koroshetz, M.D., deputy director of the NINDS.
Calcioantagonista Antihipertensivo ) frena el parkinson en un modelo de la enfermedad en ratones.
Explicado sencillamente y sin mayores exactitudes el mecanismo protector consiste en que la isradipina bloquea los canales de calcio y así hace que la neurona deteriorada que produce dopamina (son limitadas y tienden a morir especialmente en el parkinson) deje de usar calcio para activar su funcionamiento y vuelva a usar sodio como una neurona sana y joven.
La droga podría también beneficiar al hacer necesario menor dosis de medicaciones como la L-DOPA y mantenerla eficaz y no tener que usar cada vez dosis mayores como les pasa a los pacientes de parkinson.
Se habla también del posible uso preventivo y terapéutico en parkinson.
Drug slows and may halt Parkinson's disease
CHICAGO -- Northwestern University researchers have discovered a drug that slows – and may even halt – the progression of Parkinson's disease. The drug rejuvenates aging dopamine cells, whose death in the brain causes the symptoms of this devastating and widespread disease.
...
Dopamine is a critical chemical messenger in the brain that affects a person's ability to direct his movements. In Parkinson's disease, the neurons that release dopamine die, causing movement to become more and more difficult.
...
"Our hope is that this drug will protect dopamine neurons, so that if you began taking it early enough, you won't get Parkinson's disease, even if you were at risk. " said Surmeier, who heads the Morris K. Udall Center of Excellence for Parkinson's Disease Research at Northwestern. "It would be like taking a baby aspirin everyday to protect your heart."
Isradipine may also significantly benefit people who already have Parkinson's disease. In animal models of the disease, Surmeier's team found the drug protected dopamine neurons from toxins that would normally kill them by restoring the neurons to a younger state in which they are less vulnerable.
The principal therapy for Parkinson's disease patients currently is L-DOPA, which is converted in the brain to dopamine. Although L-DOPA relieves many symptoms of the disease in its early stages, the drug becomes less effective over time. As the disease progresses, higher doses of L-DOPA are required to help patients, leading to unwanted side-effects that include involuntary movements. The hope is that by slowing the death of dopamine neurons, isradipine could significantly extend the time in which L-DOPA works effectively.
"If we could double or triple the therapeutic window for L-DOPA, it would be a huge advance," Surmeier said.
...
Because he's a physiologist, Surmeier decided to investigate whether the electrical activity of dopamine neurons might provide a clue to their vulnerability. All neurons in the brain use electrical signals to do their job, much like digital computers.
First, Surmeier observed that dopamine neurons are non-stop workers called pacemakers. They generate regular electrical signals seven days a week, 24 hours a day, just like pacemaker cells in the heart. This was already known. But then he probed more deeply and discovered something very strange about these dopamine neurons.
Most pacemaking neurons use sodium ions (like those found in table salt) to produce electrical signals. But Surmeier found that adult dopamine neurons use calcium instead.
Sodium is a mild mannered ion that does its job without causing a whit of trouble to the cell. Calcium ions, however, are wild and rambunctious.
...
"The reliance upon calcium was a red flag to us," Surmeier said. Calcium ions need to be chaperoned by the cell almost as soon as they enter to keep them from causing trouble, he noted. The cell has to sequester them or keep pumping them out. This takes a lot of energy.
...
Surmeier theorized that the non-stop stress on the dopamine neurons explains why they are more vulnerable to toxins and die at a more rapid rate as we age.
...
When the neurons are young, Surmeier found they actually use sodium ions to do their work. But as the neurons age, they become more and more dependent on the troublesome calcium and stop using sodium. This calcium dependence – and the stress it causes the neurons --is what makes them more vulnerable to death.
What would happen, Surmeier wondered, if he simply blocked the calcium's route into the adult neuron cells" Would the neurons revert to their youthful behavior and start using sodium again"
"The cells had put away their old childhood tools in the closet. The question was if we stopped them from behaving like adults would they go into the closet and get them out again"" Surmeier asked. "Sure enough, they did."
When he gave the mice isradipine, it blocked the calcium from entering the dopamine neuron. At first, the dopamine neurons became silent. But within a few hours, they had reverted to their childhood ways, once again using sodium to get their work done.
"This lowers the cells' stress level and makes them much more resistant to any other insult that's going to come along down the road. They start acting like they're youngsters again," Surmeier said.
The next step will be launching a clinical study.
"This animal study suggests that calcium channel blockers, drugs currently used to reduce blood pressure, might someday be used to slow the steady progression of Parkinson's disease," said Walter J. Koroshetz, M.D., deputy director of the NINDS.
domingo, junio 10, 2007
Los 14 mejores alimentos para el cerebro
Pon buen alimento en tu cerebro cada día. Eres lo que comes. Cada célula en tu cuerpo se hace de nuevo cada 5 meses. Eres literalmente lo que comes.
En el libro Super Foods hay una lista de los 14 mejores alimentos, que son todos muy buenos para la función del cerebro. Intente incorporarlos en su dieta cada semana.
Aquí está la lista: arándanos (la mayoría de las bayas, pero especialmente arándanos), brócoli, habas (pinto, navy, lima, garbanzos, lentejas, sugar snap peas, guisantes), naranjas, avena, calabaza (puré, no pastel), salmón silvestre, espinaca, soja, té (especialmente verde), tomates, pavo (o pollo), nueces, y yogur.
Según el lugar a las "bayas" se las llama "frutos rojos" y a las "habas" chauchas, arvejas.
De:
Put good food into your brain each day. You are what you eat. Every cell in your body makes itself new every 5 months. You literally are what you eat. In the book Super Foods there is a list of the 14 best foods, which are all very good for brain function. Try to incorporate them into your diet every week. Here s the list: blueberries (most berries, but especially blueberries), broccoli, beans (pinto, navy, lima, chickpeas, lentils, sugar snap peas, peas), oranges, oats, pumpkin (squash not pie), wild salmon, spinach, soy, tea (especially green), tomatoes, turkey (or chicken), walnuts, and yogurt.
amenclinics.com
En el libro Super Foods hay una lista de los 14 mejores alimentos, que son todos muy buenos para la función del cerebro. Intente incorporarlos en su dieta cada semana.
Aquí está la lista: arándanos (la mayoría de las bayas, pero especialmente arándanos), brócoli, habas (pinto, navy, lima, garbanzos, lentejas, sugar snap peas, guisantes), naranjas, avena, calabaza (puré, no pastel), salmón silvestre, espinaca, soja, té (especialmente verde), tomates, pavo (o pollo), nueces, y yogur.
Según el lugar a las "bayas" se las llama "frutos rojos" y a las "habas" chauchas, arvejas.
De:
Put good food into your brain each day. You are what you eat. Every cell in your body makes itself new every 5 months. You literally are what you eat. In the book Super Foods there is a list of the 14 best foods, which are all very good for brain function. Try to incorporate them into your diet every week. Here s the list: blueberries (most berries, but especially blueberries), broccoli, beans (pinto, navy, lima, chickpeas, lentils, sugar snap peas, peas), oranges, oats, pumpkin (squash not pie), wild salmon, spinach, soy, tea (especially green), tomatoes, turkey (or chicken), walnuts, and yogurt.
amenclinics.com
martes, mayo 29, 2007
Citicolina mejora la memoria en ratas tratadas con bromazepam
Citicoline antagonizes bromazepam-induced amnesia in rats
X. Antón Alvarez 1 *, Begoña Vecino 1, Juan Enrique Perea 2, Danilo Daniele 2, Ramón Cacabelos 1
1EuroEspes Biomedical Research Center, A Coruña, Spain
2Laboratorios Baliarda, Buenos Aires, Argentina
email: X. Antón Alvarez ( euroespes@lcg.servicom.es )
*Correspondence to X. Antón Alvarez, Department of Neuropharmacology, EuroEspes Biomedical Research Center, Santa Marta de Babío, 15166-Bergondo, A Coruña, Spain. Tel and Fax: 34-81-78 05 05.
Funded by:
Laboratories Baliarda, Argentina
EuroEspes Foundation, Spain
Keywords
citicoline • bromazepam • acquisition • retention • memory • amnesia • motor co-ordination • exploratory activity
Abstract
Citicoline is an endogenous intermediate in the biosynthesis of brain phospholipids and acetylcholine used for the treatment of neurodegenerative processes associated with head trauma, stroke, brain aging, cerebrovascular pathology and Alzheimer's disease. In this study we have investigated the effects of citicoline on acquisition and retention in passive avoidance and spatial discriminative learning tasks in control rats and in bomazepam-treated animals. Interactions of citicoline with bromazepam on exploratory behaviour (anxiolytic/sedative activity) and motor co-ordination (myorelaxing activity) were also evaluated to test the specificity of the cognitive effects of citicoline. Our results indicate that citicoline reverses bromazepam-induced amnesia, improves retention in control rats, and has no significant effects on spontaneous activity and motor co-ordination when given alone or in combination with bromazepam. According to these results we conclude that citicoline acts as a promnesic and anti-amnesic drug with no sedative-myorelaxing activity in rats. Therefore, this compound might be of use for the specific treatment of cognitive impairments associated with the chronic use of benzodiazepines. © 1997 John Wiley & Sons, Ltd.
Digital Object Identifier (DOI)
10.1002/(SICI)1099-1077(199711/12)12:6<547::AID-HUP922>3.0.CO;2-T
wiley.com
X. Antón Alvarez 1 *, Begoña Vecino 1, Juan Enrique Perea 2, Danilo Daniele 2, Ramón Cacabelos 1
1EuroEspes Biomedical Research Center, A Coruña, Spain
2Laboratorios Baliarda, Buenos Aires, Argentina
email: X. Antón Alvarez ( euroespes@lcg.servicom.es )
*Correspondence to X. Antón Alvarez, Department of Neuropharmacology, EuroEspes Biomedical Research Center, Santa Marta de Babío, 15166-Bergondo, A Coruña, Spain. Tel and Fax: 34-81-78 05 05.
Funded by:
Laboratories Baliarda, Argentina
EuroEspes Foundation, Spain
Keywords
citicoline • bromazepam • acquisition • retention • memory • amnesia • motor co-ordination • exploratory activity
Abstract
Citicoline is an endogenous intermediate in the biosynthesis of brain phospholipids and acetylcholine used for the treatment of neurodegenerative processes associated with head trauma, stroke, brain aging, cerebrovascular pathology and Alzheimer's disease. In this study we have investigated the effects of citicoline on acquisition and retention in passive avoidance and spatial discriminative learning tasks in control rats and in bomazepam-treated animals. Interactions of citicoline with bromazepam on exploratory behaviour (anxiolytic/sedative activity) and motor co-ordination (myorelaxing activity) were also evaluated to test the specificity of the cognitive effects of citicoline. Our results indicate that citicoline reverses bromazepam-induced amnesia, improves retention in control rats, and has no significant effects on spontaneous activity and motor co-ordination when given alone or in combination with bromazepam. According to these results we conclude that citicoline acts as a promnesic and anti-amnesic drug with no sedative-myorelaxing activity in rats. Therefore, this compound might be of use for the specific treatment of cognitive impairments associated with the chronic use of benzodiazepines. © 1997 John Wiley & Sons, Ltd.
Digital Object Identifier (DOI)
10.1002/(SICI)1099-1077(199711/12)12:6<547::AID-HUP922>3.0.CO;2-T
wiley.com
domingo, mayo 13, 2007
Movimiento de ojos para mejorar la memoria
Según un estudio mover los ojos lateralmente por 30 segundos mejora la memoria al hacer que los hemisferios cerebrales interactúen más entre si.
Se le presentaron listas de palabras a los sujetos y algunos hicieron movimientos horizontales de ojos por 30 segundos, tras los cuales reconocieron más palabras.
Sugieren probar mover los ojos de esta manera cuando uno no puede recordar por ejemplo dónde dejó un objeto.
Moving Your Eyes Improves Memory, Study Suggests
If you're looking for a quick memory fix, move your eyes from side-to-side for 30 seconds, researchers say.
Horizontal eye movements are thought to cause the two hemispheres of the brain to interact more with one another, and communication between brain hemispheres is important for retrieving certain types of memories.
Se le presentaron listas de palabras a los sujetos y algunos hicieron movimientos horizontales de ojos por 30 segundos, tras los cuales reconocieron más palabras.
Sugieren probar mover los ojos de esta manera cuando uno no puede recordar por ejemplo dónde dejó un objeto.
Moving Your Eyes Improves Memory, Study Suggests
If you're looking for a quick memory fix, move your eyes from side-to-side for 30 seconds, researchers say.
Horizontal eye movements are thought to cause the two hemispheres of the brain to interact more with one another, and communication between brain hemispheres is important for retrieving certain types of memories.
lunes, abril 23, 2007
Nuevo blog de Juan Carlos
Como hacía tiempo que no sabía de las actividades de Juan Carlos me dí una vuelta por drogasinteligentes.com y veo que abrió un weblog:
blogs.periodistadigital.com/francotirador.php
Los temas prometen ser más variados que los nootrópicos y de mayor interés para los europeos. Espero que le vaya muy bien.
blogs.periodistadigital.com/francotirador.php
Los temas prometen ser más variados que los nootrópicos y de mayor interés para los europeos. Espero que le vaya muy bien.
viernes, abril 20, 2007
El propranolol disminuye la melatonina y podria usarse en depresiones estacionales
Siempre hay que tener en cuenta las interacciones de lo que uno toma y de las sustancias que las drogas tienden a disminuir. En este caso el efecto del propranolol de disminuir la melatonina es probado como tratamiento de la depresión estacional donde se altera la producción de melatonina por falta de luz.
Clinical Trial of Propranolol for Seasonal Affective Disorder
The purpose of this study is to determine what dose of a new timed-release tablet of the drug propranolol will reduce secretion of the hormone melatonin in healthy volunteers. This study will also determine whether suppressing melatonin will improve depressive symptoms in people with seasonal affective disorder (SAD).
SAD (sometimes referred to as winter depression) is a condition in which people experience depression as a result of seasonal variations in light. Human brains have a circadian pacemaker that regulates many body functions. As the seasons change and light duration varies, the circadian pacemaker regulates seasonal behavior by transmitting a signal of day length to the pineal gland, which secretes the hormone melatonin. Melatonin secretion increases in the winter as the duration of light decreases.
Otros artículos:
El propranolol se absorbe mejor de día.
Clinical Trial of Propranolol for Seasonal Affective Disorder
The purpose of this study is to determine what dose of a new timed-release tablet of the drug propranolol will reduce secretion of the hormone melatonin in healthy volunteers. This study will also determine whether suppressing melatonin will improve depressive symptoms in people with seasonal affective disorder (SAD).
SAD (sometimes referred to as winter depression) is a condition in which people experience depression as a result of seasonal variations in light. Human brains have a circadian pacemaker that regulates many body functions. As the seasons change and light duration varies, the circadian pacemaker regulates seasonal behavior by transmitting a signal of day length to the pineal gland, which secretes the hormone melatonin. Melatonin secretion increases in the winter as the duration of light decreases.
Otros artículos:
El propranolol se absorbe mejor de día.
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